Canestrin Tablet (Clotrimazole)

Adult dosage

100 mg: Generally, insert 100 mg of clotrimazole deeply into the vagina once daily at bedtime for 6 consecutive days. For short-term therapy, generally insert 200 mg of clotrimazole deeply into the vagina once daily at bedtime for 3 consecutive days. 200 mg: Generally, insert 200 mg of clotrimazole deeply into the vagina once daily at bedtime for 3 consecutive days. 500 mg: Generally, insert clotrimazole 500 mg deeply into the vagina once daily at bedtime.

This medication should not be used by individuals who are allergic to or have had hypersensitivity reactions to the active ingredient or any component of the formulation. During the use of this medication, it should not be taken with immunosuppressants such as oral Tacrolimus or Sirolimus, as this may increase the blood concentration and risk of side effects. Therefore, patients using this medication should carefully monitor their blood concentration under medical supervision. Women who are pregnant or may become pregnant should consult a healthcare professional before using this medication. Although no significant issues were found in animal studies, caution should be exercised during early pregnancy due to an increased risk of spontaneous abortion. The risk is relatively low during the second and third trimesters. Additionally, it is advisable to avoid the use of insertion devices when using vaginal suppositories during pregnancy. Nursing mothers are advised to discontinue breastfeeding during the treatment period, as the components of this medication can be excreted in breast milk. If severe allergic reactions or symptoms such as skin rash, itching, swelling, vaginal bleeding, or abdominal pain occur while using this medication, it should be discontinued immediately, and consultation with a healthcare professional should be sought. It is advisable not to use this medication during menstruation, and additional drug treatment may be necessary for specific infections. Furthermore, sexual partners should also receive treatment to prevent reinfection, and personal hygiene should be maintained to prevent reinfection. During the use of this medication, it is best to avoid other vaginal insertion products such as tampons, vaginal cleansers, and douches, and to refrain from vaginal intercourse. Care should also be taken to avoid contact with the eyes and to prevent ingestion. If symptoms such as high fever, lower abdominal pain, foul-smelling vaginal discharge, nausea, or vaginal bleeding occur, immediate consultation with a healthcare professional is necessary. In case of overdose, there is no specific antidote, but the risk of acute toxicity is low. However, if a large quantity is mistakenly ingested, it is advisable to visit a medical institution promptly for appropriate treatment. This medication may weaken latex products such as condoms or vaginal contraceptive diaphragms, so caution should be exercised when using them together. This medication is for vaginal use only and should not be taken orally. It is intended for use in individuals aged 12 years and older. When storing, keep it out of the reach of children and tightly close the original container. It is recommended to store it in a cool, dry place, away from direct sunlight.

Serious side effects

• Syncope
• hypotension
• shortness of breath
• hives
• high fever
• lower abdominal pain
• vaginal bleeding
• shoulder pain

Mild side effects

• Skin peeling in the genital area
• itching
• rash
• swelling (edema)
• erythema (red spots)
• discomfort
• burning sensation
• irritation
• pelvic pain
• vaginal bleeding

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. The storage temperature should be maintained between 1°C and 30°C.

Appearance

White or pale yellow rectangular vaginal tablet

Package unit

600 tablets/[(1 tablet/package x 600)]