Medibrex Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient and may be administered regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or divide the dose into 100 mg per dose twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg per dose twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, another treatment method should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may pose a risk of gastrointestinal bleeding in individuals who consume more than three alcoholic beverages regularly each day, so consultation with a physician or pharmacist is essential before use. This medication can affect the cardiovascular system and may increase the risk of serious thrombotic events such as myocardial infarction or stroke, so it should only be used at the minimal effective dose and for the shortest duration necessary. During treatment, if cardiovascular symptoms such as chest pain, shortness of breath, weakness, or difficulty speaking occur, immediate consultation with healthcare professionals is required. This medication can cause serious gastrointestinal issues such as ulcers, bleeding, or perforation; therefore, individuals with a history of gastrointestinal disease or the elderly should exercise particular caution, and seek immediate treatment if gastrointestinal bleeding symptoms are suspected. This medication may cause specific allergic reactions; individuals with hypersensitivity to this medication or its components or those with sulfonamide allergies should avoid use. Individuals with a history of asthma, acute rhinitis, nasal polyps, angioedema, or urticaria should avoid taking this medication. Patients with severely impaired liver or kidney function, active peptic ulcer disease or gastrointestinal bleeding, heart failure, ischemic heart disease, pregnant women, and nursing mothers should not use this medication. Caution is advised for patients with liver or kidney impairment, a history of hypertension or heart failure, and the elderly, and regular monitoring through laboratory tests is required to check for abnormalities. During treatment, side effects such as headache, dyspepsia, diarrhea, dizziness, insomnia, skin rash, edema, hypertension, etc., may occur, and if symptoms are severe, consultation with a physician is required. This medication is metabolized in the liver; therefore, blood concentrations may change if used with other medications that affect liver metabolism, so it is essential to inform healthcare providers of all medications currently being taken. Particular caution is advised when used in combination with blood pressure medications, diuretics, anticoagulants, antidepressants, antiarrhythmics, lithium, methotrexate, etc., and regular blood tests and kidney function tests are required. Women who are pregnant or may become pregnant should not take this medication, and should discontinue if pregnancy is detected while taking it. This medication is also excreted in breast milk, so nursing mothers should avoid taking it. Dizziness or drowsiness may occur when taking this medication, so care should be taken when driving or operating machinery. Short-term use of this medication is recommended, and if used long-term, regular complete blood counts, and liver and kidney function tests should be performed. In case of overdose, symptoms such as nausea, vomiting, drowsiness, increased blood pressure, and renal failure may appear, requiring immediate emergency treatment.

Gastrointestinal bleeding, cardiovascular thrombotic events, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, pruritus, rash, urticaria, petechiae, angioedema, alopecia, bullous pemphigoid, peripheral edema, facial swelling, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal impairment, acute renal failure, interstitial nephritis, headache, migraine, neuralgia, neuropathy, paresthesia, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, allergic reaction, weakness, chest pain, fluid retention, generalized edema, facial edema, fatigue, malaise, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, angioedema, insomnia, appetite loss, increased appetite, depression, nervous hyperreactivity, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory infection, herpes zoster, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, chest pain, dysmenorrhea, menstrual disorder, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, abnormal liver function, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urinary urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, elevated NPN, increased creatinine, increased alkaline phosphatase, weight gain, increased LDH, hypoglycemia, hyponatremia, synovial cavity, arthralgia, arthrosis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in various regions, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, angioedema, contact dermatitis, injection site reaction, skin nodules, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal-change disease, menstrual disorders, chest pain, anaphylactic reaction, hallucinations, cerebral hemorrhage, aseptic meningitis, ageusia, anosmia, conjunctivitis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized pustular exanthema, exfoliative dermatitis, generalized bullous fixed drug eruption, fixed drug eruption, acute renal failure, hyponatremia

This medication should be stored in a tightly sealed container to protect it from air, and should ideally be kept at room temperature between 15 and 30 degrees Celsius. This will help maintain the medication's effectiveness and prevent degradation.

Appearance

A white capsule filled with white to slightly yellow powder with yellow stripes on the top and bottom.

Package unit

Bottle - 30 capsules/bottle, Bottle - 100 capsules/bottle, Bottle - 500 capsules/bottle