Medication info

Propirodine (Propiverine Hydrochloride)

Prescription medicationApproval withdrawn
Ingredient · strength
Propiverine Hydrochloride›Strength being verified
Manufacturer / importer
Cosmax Pharma Co., Ltd.
Appearance
White round film-coated tablets
Packaging
30 tablets/bottle, 100 tablets/bottle
Approval status
Approval withdrawn

MFDS item code 201900881 · Approved 2019.02.12

This product's status changed to Approval withdrawn on 2023.07.19. It may no longer be sold, so consult a doctor or pharmacist before taking it.

Summary

Main use
Relief of overactive bladder symptoms (such as urinary urgency) and urinary frequency and incontinence associated with bladder disorders
Who uses it
Adults
Adult dosage
Adults: Administer 20 mg of propiverine hydrochloride orally once daily after a meal. Adjust the dose appropriately according to symptoms; however, if the effect is insufficient and there are no safety concerns, 20 mg may be taken twice daily.

Ingredients

Manufacturer
Cosmax Pharma Co., Ltd.

Efficacy & effects

Relief of overactive bladder symptoms (such as urinary urgency) and urinary frequency and incontinence associated with bladder disorders

  • Frequent urination
  • incontinence
  • neurogenic bladder
  • neurogenic frequency
  • unstable bladder
  • bladder irritation state
  • chronic cystitis
  • chronic prostatitis
  • urinary urgency
  • urge incontinence
View approved original text

This medication is used for frequent urination and incontinence caused by conditions such as neurogenic bladder, neurogenic frequency, and unstable bladder. It also helps improve symptoms caused by bladder irritation due to chronic cystitis or chronic prostatitis. It is effective in treating urinary urgency, frequency, and urge incontinence that occur due to overactive bladder. In other words, it alleviates various symptoms associated with bladder dysfunction, thereby enhancing the quality of life of patients. This drug contributes to stabilizing the bladder and improving symptoms.

Dosage and Administration

Adult dosage

Adults: Administer 20 mg of propiverine hydrochloride orally once daily after a meal. Adjust the dose appropriately according to symptoms; however, if the effect is insufficient and there are no safety concerns, 20 mg may be taken twice daily.

Precautions

This medication should not be administered to certain patients. For example, patients who have had allergic reactions to this medication or its components, those with gastrointestinal or intestinal obstruction, patients with weak gastrointestinal mobility, those who have difficulty urinating, patients with angle-closure glaucoma, patients with myasthenia gravis, and patients with severe heart disease may experience worsening of symptoms if they use this medication. Additionally, patients with urinary retention issues, liver or kidney dysfunction, as well as elderly individuals and those with diseases like Parkinson's disease or hyperthyroidism should use this medication cautiously. This drug is primarily metabolized in the liver, so adverse reactions may occur more frequently in patients with poor liver function. While using this medication, there may be symptoms of mental disturbances or gastrointestinal issues, cardiac arrhythmias, blood disorders, renal dysfunction, skin rashes, eye pain or vision impairment, liver dysfunction, muscle pain, etc., so if symptoms occur, consult a doctor immediately. This medication can cause drowsiness, dizziness, and difficulty in eye accommodation, so it is advisable to avoid driving or operating hazardous machinery. Moreover, when taken in combination with anticholinergics or certain antidepressants, side effects may be increased, so consultation with a specialist is essential. It is recommended to avoid the use of this medication in pregnant women, women who may become pregnant, nursing mothers, and children, as safety has not been established. Elderly patients should start with a lower dose considering potential declines in liver and kidney function for safety. In case of overdose, symptoms like confusion, convulsions, walking difficulties, urinary problems, cardiac arrhythmias, etc., may occur, so immediate medical attention is required for appropriate treatment. Finally, this medication should be stored out of reach of children, and transferring it to another container may lead to quality deterioration or accidents, so caution is advised.

Side effects

  • Hallucinations
  • delirium
  • paralytic ileus
  • severe constipation
  • abdominal distension
  • palpitations
  • ectopic beats
  • bradycardia
  • QT prolongation
  • ventricular tachycardia
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  • atrioventricular block
  • thrombocytopenia
  • renal impairment
  • urinary retention
  • skin and mucous membrane syndrome
  • fever
  • erythema
  • itching
  • conjunctival injection
  • stomatitis
  • ocular hypertension
  • acute angle-closure glaucoma attack
  • nausea
  • headache
  • vision impairment
  • hepatic dysfunction
  • jaundice
  • myalgia
  • lethargy
  • increased CK
  • rhabdomyolysis
  • dizziness
  • headache
  • numbness
  • drowsiness
  • insomnia
  • tremors
  • altered consciousness
  • perceptual disturbances
  • transient forgetfulness
  • Parkinsonian symptoms
  • dyskinesia
  • hypotension
  • hypertension
  • chest pain
  • hypersensitivity
  • itching
  • rash
  • urticaria
  • control disorders
  • dry eye syndrome
  • increased AST
  • increased ALT
  • increased ALP
  • increased BUN
  • increased creatinine
  • leukopenia
  • fatigue
  • malaise
  • edema
  • weakness
  • taste disturbance
  • low back pain
  • hoarseness
  • sputum
  • agitation
  • heat due to decreased sweating
  • weakness
  • pharyngitis
  • delirium
  • agitation
  • generalized seizures
  • gait abnormalities
  • speech disorders
  • mydriasis
  • urinary retention
  • tachycardia
  • hypertension
  • generalized flushing
  • liver dysfunction

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is best to maintain a storage temperature at room temperature between 1 to 30 degrees Celsius. This helps to keep the drug's efficacy and safety for an extended period.

Appearance and packaging

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.