Medication info
New Rabe Tablet 20mg (Rabeprazole Sodium)

New Rabe Tablet 20mg (Rabeprazole Sodium)

Prescription medicationTablet경구
Ingredient · strength
Rabeprazole Sodium›20mg / 1 tablet
Manufacturer / importer
(주)시어스제약
Appearance
Pale yellow round enteric coated tablet
Packaging
28 tablets (14 tablets/Alu-Alu packaging x 2)
Approval status
Active

MFDS item code 201900849 · Approved 2019.02.11 · Insurance code 689000510

Summary

Main use
Relief of symptoms of gastric ulcer, duodenal ulcer, and gastroesophageal reflux disease.
Who takes it
Adults
Adult dose
Gastric ulcer, duodenal ulcer: Usually, 10 mg is administered orally once daily. Depending on symptoms, 20 mg may be administered orally once daily. Usually, treatment is given for up to 8 weeks for gastric ulcers and 6 weeks for duodenal ulcers. Erosive or ulcerative gastroesophageal reflux disease: 10 mg or 20 mg once daily for 4 to 8 weeks. If treatment is still insufficient after 8 weeks, an additional 8 weeks of 10 mg or 20 mg may be administered.

Ingredients

Manufacturer
(주)시어스제약

Efficacy & effects

Relief of symptoms of gastric ulcer, duodenal ulcer, and gastroesophageal reflux disease.

  • Gastric ulcer
  • duodenal ulcer
  • erosive gastroesophageal reflux disease
  • ulcerative gastroesophageal reflux disease
  • symptoms of gastroesophageal reflux disease
  • Zollinger-Ellison syndrome
View approved original text

This medication is used to treat ulcers that occur in the stomach and duodenum and to relieve symptoms of gastroesophageal reflux disease. It is also effective for long-term maintenance therapy of gastroesophageal reflux disease and increases treatment efficacy when used in conjunction with antibiotics for patients with gastric ulcers infected with Helicobacter pylori. It helps with disorders of excessive gastric acid secretion, such as Zollinger-Ellison syndrome. It safely and effectively acts on various gastrointestinal diseases, improving patients' symptoms.

How to take

Adult dose

Gastric ulcer, duodenal ulcer: Usually, 10 mg is administered orally once daily. Depending on symptoms, 20 mg may be administered orally once daily. Usually, treatment is given for up to 8 weeks for gastric ulcers and 6 weeks for duodenal ulcers. Erosive or ulcerative gastroesophageal reflux disease: 10 mg or 20 mg once daily for 4 to 8 weeks. If treatment is still insufficient after 8 weeks, an additional 8 weeks of 10 mg or 20 mg may be administered.

Precautions

This medication should not be used in patients with specific allergic reactions. For example, patients who have hypersensitivity to this medication, its components, or to benzimidazoles, or those who have had such experiences in the past should not take it. Additionally, when used in combination with amoxicillin or clarithromycin for the eradication of Helicobacter pylori, patients with hypersensitivity reactions to those antibiotics should also not use this medication. Patients taking certain heart-related medications (terfenadine, cisapride, pimodivir, astemizole) or atazanavir, rilpivirine should not use this medication in combination. Pregnant or nursing women should not take this medication, and caution is required for patients with impaired liver function, elderly patients, and those with a history of drug allergies. During the use of this medication, allergic symptoms such as rashes, hives, or itching may occur; if such symptoms develop, the use should be stopped immediately. Regular blood tests and liver function tests are necessary, and appropriate action should be taken if any abnormalities are found. Side effects can occur in various areas including cardiovascular, gastrointestinal, central nervous system, respiratory, musculoskeletal, skin, eyes, and urogenital systems, so immediate consultation with a healthcare professional is required if any unusual symptoms occur. Since this medication inhibits gastric acid secretion, there may be an increased risk of fractures with long-term use, and magnesium deficiency can rarely occur, so it is important for long-term users to regularly check magnesium levels. There is a slight increase in the risk of gastrointestinal bacterial infections, so if diarrhea persists or worsens, it is necessary to inform healthcare providers. Caution is required when driving or operating machinery as drowsiness may occur. Interactions with other medications may occur, so patients taking anticoagulants, methotrexate, antibiotics, antivirals, etc., should inform their healthcare providers, and caution is required with combination therapy. This medication should not be chewed or crushed and should be swallowed whole; it should be kept out of reach of children. Long-term use of this medication may lead to vitamin B12 absorption disorders, so nutritional status should be checked if necessary. Finally, symptoms of gastric cancer or other malignant tumors may be masked during the use of this medication, so it is essential to consult a specialist if unintended weight loss, recurrent vomiting, difficulty swallowing, hematemesis, or melena occurs.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, fulminant hepatitis, liver dysfunction, jaundice, interstitial nephritis, acute interstitial nephritis, hepatic encephalopathy, shock, anaphylactic response, angioedema, arrhythmias including ventricular tachycardia, ventricular fibrillation, Torsades de pointes, fever, cough, respiratory distress, pulmonary auscultatory abnormalities, severe cutaneous adverse reactions (severe rashes, blisters, skin shedding along with high fever).

Mild side effects

  • Rash
  • hives
  • itching
  • erythrocytopenia
  • leukopenia
  • leukocytosis
  • eosinophilia
  • neutrophilia
  • lymphocytopenia
  • anemia
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  • petechial hemorrhage
  • lymphadenopathy
  • hypopigmented anemia
  • pancytopenia
  • agranulocytosis
  • thrombocytopenia
  • hemolytic anemia
  • elevated ALT
  • elevated AST
  • elevated ALP
  • elevated γ-GTP
  • elevated LDH
  • increased total bilirubin
  • hypertension
  • myocardial infarction
  • ECG abnormalities
  • migraine
  • syncope
  • angina
  • complete heart block.

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly closed container to prevent air or moisture from entering. It is recommended to maintain the storage temperature between 1 degree and 30 degrees Celsius room temperature. This helps to preserve the medication's effectiveness.

Appearance and packaging

Appearance

Pale yellow round enteric coated tablet

Package unit

28 tablets (14 tablets/Alu-Alu packaging x 2)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.