Medication info
Ambesque 5mg Tablets (Amlodipine Besilate)

Ambesque 5mg Tablets (Amlodipine Besilate)

Prescription medicationTablet경구
Ingredient · strength
Amlodipine Besylate›6.944mg / 1 tablet
Manufacturer / importer
(주)보령바이오파마
Appearance
White octagonal tablet
Packaging
30 tablets/bottle, 500 tablets/bottle
Approval status
Active

MFDS item code 201900679 · Approved 2019.01.25 · Insurance code 670501250

Summary

Main use
Efficacy in treating myocardial ischemia caused by hypertension and coronary artery disease (stable and variant angina) and in reducing the risk of angina-related hospitalization and vascular revascularization.
Who takes it
Adults
Adult dose
Adults should take 5 mg orally once daily as amlodipine, and the dose may be increased up to a maximum of 10 mg per day depending on the patient's response. The dose should be adjusted according to age and symptoms.

Ingredients

Manufacturer
(주)보령바이오파마

Efficacy & effects

Efficacy in treating myocardial ischemia caused by hypertension and coronary artery disease (stable and variant angina) and in reducing the risk of angina-related hospitalization and vascular revascularization.

  • Hypertension
  • fixed obstruction of coronary arteries
  • coronary vasospasm
  • vasoconstriction
  • myocardial ischemia
  • angina
View approved original text

This medication is used to treat stable angina, as well as myocardial ischemia caused by fixed obstruction of the coronary arteries and vasospastic angina. It is also effective in reducing the risk of hospitalization due to angina in patients with verified coronary heart disease during recent angiography who do not have heart failure and have a cardiac output of 40% or more, as well as in reducing risks associated with coronary vascular revascularization. This helps improve heart health by assisting in the treatment and risk reduction of cardiovascular-related diseases.

How to take

Adult dose

Adults should take 5 mg orally once daily as amlodipine, and the dose may be increased up to a maximum of 10 mg per day depending on the patient's response. The dose should be adjusted according to age and symptoms.

Precautions

This medication should not be used in certain patients. For instance, it is contraindicated in patients with allergies to this drug or similar drugs, nursing women, patients with severe liver dysfunction, severe aortic stenosis patients, and those in shock. Care should be taken when administering this drug to patients with severe hypotension, patients requiring dialysis due to renal failure, the elderly, and women who are pregnant or may become pregnant. Side effects may include flushing, fatigue, edema, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea. Rarely, symptoms such as low blood pressure, vasculitis, sensory abnormalities, erectile dysfunction, dry mouth, hepatitis, and skin rash may occur, and if any unusual symptoms arise, medical advice should be sought immediately. Patients with heart failure or impaired liver function may have slower metabolism and excretion of this medication, requiring dose adjustment and caution. Additionally, since the effect of this medication appears slowly, it may not be suitable in emergency situations. It is advisable to avoid consuming grapefruit or grapefruit juice while taking this medication. Co-administration with certain drugs may increase side effects such as hypotension, so it is important to inform healthcare professionals if taking other medications. The safety of this medication has not been established for use during pregnancy or lactation, and it should only be used cautiously if no alternative medications are available and the risk is significant, with breastfeeding recommended to be discontinued. In children, use is only recommended for those aged 6 years or older, as safety and efficacy have not been confirmed for those under 6 years of age. Overdose can lead to severe hypotension and heart problems, requiring immediate emergency treatment, and this medication is not removed by blood dialysis, thus may require special treatment. Lastly, though this medication is known not to substantially affect the ability to drive or operate machinery, caution is advised as individuals may experience dizziness or drowsiness.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes with high fever, blisters, skin peeling, pain in oral/ocular mucous membranes, severe skin adverse reactions, shortness of breath or difficulty in breathing, asthma attack, respiratory issues accompanied by cough and fever, breathing problems, jaundice (yellowing of the skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden and

Mild side effects

  • Flushing
  • fatigue
  • edema
  • palpitations
  • dizziness
  • headache
  • drowsiness
  • abdominal pain
  • nausea
  • weakness
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  • lethargy
  • pain
  • weight gain/loss
  • hypotension
  • vasculitis
  • tension
  • sensory decrease/sensory abnormality
  • peripheral neuropathy
  • syncope
  • taste alteration
  • tremor
  • extrapyramidal disorder
  • erectile dysfunction
  • gynecomastia
  • changes in bowel habits
  • dry mouth
  • dyspepsia
  • gingival hyperplasia
  • pancreatitis
  • vomiting
  • hyperglycemia
  • arthralgia
  • low back pain
  • muscle cramps
  • myalgia
  • leukopenia

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is recommended to keep it at room temperature between 1 degree and 30 degrees Celsius. This helps maintain the effectiveness of the medication for a longer period.

Appearance and packaging

Appearance

White octagonal tablet

Package unit

30 tablets/bottle, 500 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.