Plakim 75 mg (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel 75 mg orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start with a loading dose of 300 mg of this medicine orally once daily on the day treatment is initiated, followed by a maintenance dose of 75 mg orally once daily. Aspirin 75 ～ 325 mg should be administered concomitantly with this medicine once daily. 3. For patients with atrial fibrillation, administer 75 mg of this medicine orally once daily. Aspirin 75 ～ 100 mg should be administered concomitantly with this medicine once daily. ○ Patients with renal impairment : Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment : Treatment experience in patients with moderate hepatic disease and a bleeding diathesis is limited. This medicine may be taken with or without food.

This medication helps to prevent platelet aggregation to facilitate proper blood flow. When taking this medication, it is important to consult a doctor if the individual has a genetically low function of a specific enzyme (CYP2C19) as the drug's effectiveness may be reduced. Additionally, certain medications should not be used together with this drug as they may increase the risk of bleeding. Patients with hypersensitivity to this medication, severe bleeding, significant liver impairment, nursing women, or patients with lactose intolerance should not use it. Patients at high risk of bleeding or those scheduled for surgery should be cautious while taking this medication and must report any bleeding symptoms to their doctor immediately. This medication can prolong bleeding time, which may complicate wound healing or hemostasis post-surgery, thus caution is advised. Regular blood tests to monitor bleeding risk or platelet counts are important. While taking this medication, gastrointestinal disturbances, diarrhea, headaches, rashes, and other side effects may occur; if symptoms are severe, consult a healthcare professional. Elderly individuals or patients with renal impairment may experience side effects more readily, thus dosage adjustment and monitoring are necessary. During pregnancy or nursing, consultation with a doctor is essential, and particularly around labor, there may be a need to discontinue the medication due to bleeding risks. Overdose may increase the risk of bleeding; in such cases, immediate medical attention is required to receive appropriate treatment. This medication has not been established as safe or effective in children, so it's advisable not to use it in this population. During the course of treatment, any new medication initiation or surgery should be communicated to healthcare providers. Lastly, keep this medication out of reach of children and do not transfer it to other containers for safety.

Bleeding, gastrointestinal bleeding, bleeding requiring hospitalization, purpura, contusion, hematoma, epistaxis, hematoma, hematuria, intraocular hemorrhage, intracranial bleeding, major bleeding, life-threatening bleeding, fatal bleeding, hemorrhagic stroke, need for hemostatic agents, need for transfusion, significant functional impairment, intraocular hemorrhage accompanied by significant vision loss, minor bleeding, neutropenia, agranulocytosis, aplastic anemia, thrombocytopenia, skin and appendage adverse reactions, rash, pruritus, diarrhea, abdominal pain, dyspepsia, nausea, headache, dizziness, depression, upper respiratory tract infection, dyspnea, rhinitis, bronchitis, cough, urinary tract infection, chest pain, accidental injury, influenza-like illness, pain, fatigue, edema, hypertension, intracranial hemorrhage, purpura, bloody stools, thrombocytopenia, anemia, hematoma, hematuria, hemoptysis, muscle bleeding, gum bleeding, cough, dyspnea, rhinitis, visual disturbances, field defects, dry eye syndrome, transient blindness, congestion, tinnitus, taste disturbance, taste loss, vasculitis, hypotension, bronchospasm, interstitial pneumonia, eosinophilic pneumonia, colitis, pancreatitis, gastritis, stomatitis, hepatitis, acute liver failure, petechial rash, erythematous rash, urticaria, angioedema, vesicular dermatitis, drug-induced hypersensitivity syndrome, eosinophilia, drug rash, eczema, lichen planus, arthralgia, arthritis, myalgia, glomerular disease, gynecomastia, fever, abnormal liver function tests, increased blood creatinine, reduced exercise ability, tremor, speech impairment, abnormal gait, hyperactivity, ataxia, paresthesia, insomnia, depression, amnesia, anxiety, confusion, abnormal behavior, rigidity, facial edema, syncope, cholecystitis, hematemesis, spinal hematoma, thrombocytopenia, hypochromic anemia, leukemia, leukopenia, eosinophilia, menorrhagia, hemothorax, herpes zoster, renal dysfunction, acute renal failure

This medication may be sensitive to air and moisture, so it should be stored in a sealed container. It is advisable to maintain the storage temperature between 1 to 30 degrees Celsius at room temperature to preserve the effectiveness of the medication.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle