Coxiwon Capsule 100 mg (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted for each patient. It may be taken with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks at 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be discussed with a doctor or pharmacist if taken by individuals who regularly consume more than three alcoholic drinks a day, as there is a higher risk of gastrointestinal bleeding. This medication may increase the risk of serious cardiovascular issues such as thromboembolic events, myocardial infarction, and stroke, so it should be used at the lowest effective dose for the shortest duration necessary. If cardiovascular symptoms such as chest pain, shortness of breath, weakness, or speech changes occur, seek medical attention immediately. This medication may increase the risk of gastrointestinal perforation, ulcers, and bleeding, especially in elderly patients or those with a history of gastrointestinal disorders. If symptoms such as epigastric pain, indigestion, black stools, or hematemesis occur, report immediately to medical personnel. Patients with hypersensitivity to this medication or a history of sulfonamide allergy, or who have had allergic reactions to non-steroidal anti-inflammatory drugs such as aspirin, should not take this medication. Patients with severely impaired liver or kidney function, active peptic ulcers, inflammatory bowel disease, established heart failure, or cardiovascular disease should also avoid this medication. Pregnant or nursing women and those who might become pregnant should not take this medication, and if pregnancy occurs during treatment, it must be stopped immediately. Caution is advised when administering this medication to patients with liver disease, kidney disease, hypertension, heart failure, asthma, elderly individuals, and those with diabetes, under the direction of a doctor. Regular monitoring of blood pressure, liver function, and kidney function is necessary during treatment, and if any abnormal symptoms occur, consult a physician immediately. This medication may interact with various other medications, so always inform your healthcare provider of other medications you are taking, particularly antihypertensives, anticoagulants, diuretics, antidepressants, and antiarrhythmics. Dizziness or drowsiness may occur with this medication, so it is advisable to avoid driving or operating machinery. Long-term use requires regular blood tests and monitoring of liver and kidney function, and if any adverse reactions occur, discontinue use and consult medical personnel. An overdose may result in lethargy, drowsiness, nausea, vomiting, and abdominal pain, requiring immediate medical intervention. This medication should be kept out of reach of children and should not be transferred to other containers for safety.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, liver enzyme elevation, itching, rash, urticaria, angioedema, alopecia, bullous dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, frequency of urination, kidney stones, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, elevated serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, headache, leg cramp, muscle tension, sensory reduction, migraine, neuralgia, neuropathy, sensory disturbance, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, back pain, exacerbation of allergy, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, loss of appetite, increased appetite, depression, neuro-excitability, drowsiness, fatal intracranial hemorrhage, hallucination, exacerbation of epilepsy, upper respiratory tract infection, sinusitis, pharyngitis, rhinitis, bronchospasm, worsening bronchospasm, shortness of breath, laryngitis, pneumonia, nosebleed, voice disorder, vesicular dermatitis, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, maculopapular rash, skin disease, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, eczema, lipoma, drug rash, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, acute renal failure, hyponatremia, menstrual disorders, chest pain, anaphylactic reaction, hallucination, intracranial hemorrhage, aseptic meningitis, loss of taste, loss of smell

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and kept in a cool place between 15 to 30 degrees Celsius. Proper storage will maintain the medication's effectiveness and prevent degradation.

Appearance

A white capsule containing a powder that is white to yellowish, with blue stripes on the top and bottom.

Package unit

100 capsules/bottle, 30 capsules/bottle