Youzenta Duo Tablet 2.5/850 mg

Adult dose

The dosage of this drug should be determined based on the maximum recommended dosages for the ingredients: linagliptin 2.5 mg and metformin 1000 mg not exceeding twice daily, taking into consideration each patient's current therapy, efficacy, and tolerance. This drug is administered twice daily with meals. 1. If currently not receiving metformin treatment: Take this drug 2.5/500 mg twice daily, 1 tablet at a time, and can increase to 2.5/1000 mg.

This drug may cause serious side effects such as lactic acidosis, so it should not be administered to patients with poor kidney function, heart disease, or liver dysfunction. Patients who are allergic to the main ingredients of this drug or patients with type 1 diabetes, pregnant women, and nursing mothers should also refrain from use. Due to the risk of hypoglycemia, blood sugar should be closely monitored when used in conjunction with insulin or sulfonylurea medications, and dosage adjustments may be necessary if needed. Patients with decreased kidney function should undergo regular kidney function tests before and during treatment with this drug, and it should be avoided in cases of significant kidney function impairment. Patients with heart failure should also be treated with caution, and if symptoms of acute pancreatitis or blistering dermatosis occur, the drug should be stopped immediately and a physician should be consulted. This drug may lower vitamin B12 levels, so patients taking it long-term should regularly check their vitamin B12 levels. If iodinated contrast agents are required for radiological examinations, this drug should be stopped for a certain period before and after the examination, and it should be re-administered only after confirming safety through kidney function testing. Patients scheduled for surgery should stop taking this drug 48 hours prior to the surgery and resume after confirming that kidney function has normalized post-surgery. Women who are pregnant or may become pregnant should not take this drug and should consider using insulin for blood sugar control. Elderly patients often have reduced kidney function, so it’s safe to frequently check kidney function and start treatment at the lowest dose when taking this drug. This drug is not recommended for children or those under 10 years of age. In cases of overdose, lactic acidosis may occur, so immediate medical attention should be sought, and hemodialysis may be necessary. This drug should be kept out of reach of children and stored away from moisture. It is advisable to avoid alcohol consumption while taking this drug, and there may be potential interactions with other medications, so consultation with a physician or pharmacist is recommended. The impact on driving or operating machinery is not clear, so caution is advised.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, blistering dermatosis, abnormal liver function (including abnormal liver function tests, hepatitis, erythema), severe allergic reactions (urticaria, angioedema), severe skin adverse reactions (rash, blistering dermatosis), serious neurological symptoms (headache, cerebral infarction, subdural effusion, confusion, coma), respiratory problems (dyspnea, asthma attacks, exercise-induced dyspnea), severe edema (eye).

Mild side effects

Infections and parasitic infections (e.g., rhinitis, bronchitis, pneumonia), metabolic and nutritional disorders (e.g., decrease in vitamin B12, decreased appetite), hypoglycemia, taste disturbance, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, abnormal liver function tests, hepatitis, pruritus, erythema, rash, severe and disability-associated arthralgia, increased lipase and amylase in clinical tests, oral ulcer formation, fatigue, chest discomfort, weakness.

This drug is sensitive to air and moisture, so it must be stored in a tightly sealed container. The storage temperature should be maintained between 1 to 30 degrees Celsius. This will help preserve the effectiveness of the medication for a longer period.

Appearance

Bright orange, biconvex, oval film-coated tablet

Package unit

60 tablets (10 tablets/PTP packaged x 6)