Hyaluna5 (Pre-filled) (Sodium Hyaluronate)

Adult dosage

As Sodium Hyaluronate, administer 25mg once a week for 5 consecutive weeks intra-articularly into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or tendon sheath of the biceps brachii). Adjust the frequency of administration appropriately based on symptoms. This drug is administered intra-articularly and should be conducted under strict aseptic conditions.

This medication should not be used in certain patients. First, patients who have had an allergic reaction to this drug or any of its components should not take it. Also, patients with skin diseases or infections at the injection site should not use this drug as it is administered intra-articularly. It is also advisable for patients with liver dysfunction or a history of liver disease to avoid using this medication. Patients allergic to avian proteins should be cautious. This drug may cause side effects, so caution is required. In severe cases, shock reactions may occur, so the patient's condition should be closely monitored after administration. If swelling, rash, hives, itching, or other allergic symptoms occur in the face or around the eyes, the use should be immediately discontinued, and treatment should be sought. Temporary pain, swelling, redness, warmth, pressure, or bruising may occur at the injection site, and severe side effects may very rarely appear. Additionally, systemic symptoms like nausea, vomiting, fever, or headache may occur. Administering this drug to joints with severe inflammation may exacerbate symptoms, so it is advisable to calm the inflammation first before use. After administration, it is necessary to stabilize the joint area and avoid excessive movement. If the drug leaks outside the joint, it may cause pain, so it should be injected precisely within the joint. Patients with rheumatoid arthritis or gouty arthritis may experience a temporary increase in inflammation, so caution is advised. For 48 hours after administration, patients should avoid vigorous activities such as jogging or tennis, or any prolonged activities that bear weight. Safety and efficacy of this drug when used in conjunction with other intra-articular injection drugs have not been confirmed, so it is best not to combine them. Women who are pregnant or may become pregnant should use this medication cautiously only when the benefits of treatment outweigh the risks, as its safety has not been fully established. Moreover, this medication may be partially transmitted through breast milk, so breastfeeding should be avoided during treatment. Safety has not been adequately established for children, so it should be used cautiously only when absolutely necessary. Elderly patients may have reduced bodily function, so they should use this medication with special care. Sterile conditions must be strictly maintained during injection, and it is recommended not to administer more than five doses if symptoms do not improve. If there is a significant accumulation of joint fluid, it may be necessary to remove the fluid before injection. This medication should not be injected into blood vessels and is not suitable for ophthalmic use. Due to its high viscosity, a properly sized needle should be used for injection, and any drug solution on the ampoule should be drawn slowly into the syringe after swirling to let it flow down. When cutting the ampoule, it is safest to clean it with a cloth to prevent foreign substances from entering. Caution should also be taken as a precipitate may form if used with certain disinfectants. This drug is for single use, so it should be used quickly after opening, and any remaining drug should be discarded. Administering a local anesthetic before the injection may help alleviate pain.

Serious side effects

• Hives
• swelling (of the face, eyelids, etc.)
• shock

Mild side effects

• Facial flushing
• itching
• transient pain
• swelling
• edema
• redness
• warmth
• significant localized pressure
• petechiae
• nausea

This medication should be stored in a sealed container to avoid contact with air and at a temperature between 1 to 30 degrees Celsius (room temperature). Proper storage will help maintain the drug's efficacy and ensure safe use.

Appearance

A colorless, transparent, viscous solution filled in a glass vial capped with rubber stoppers at both ends (part of the pre-filled syringe system)

Package unit

2.5 milliliters × 10, 50, 100 vials