Seremed Capsule 100 mg (Celecoxib)

Adult dose

The minimum recommended dose of this product should be adjusted according to the patient and may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment with 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

Caution should be taken when this medication is used by individuals who consume large amounts of alcohol daily, as the risk of gastrointestinal bleeding may increase; medical consultation is necessary. This medication could increase the risk of cardiovascular problems, especially for those with a history of cardiovascular disease or risk factors, and should be taken at the minimum dose for the shortest duration. Gastrointestinal ulcers or bleeding may occur, and elderly patients or those with a history of gastrointestinal disorders should exercise greater caution. Those allergic to this medication or having certain conditions (severe liver or kidney impairment, active peptic ulcer, heart failure, etc.) should not take it. Patients with impaired liver or kidney function, asthma, hypertension, heart failure, diabetes, etc. should exercise caution when using this medication and monitor their condition regularly. During therapy, symptoms such as dyspepsia, abdominal pain, dizziness, headache, skin rash, itching, edema, and increased blood pressure may occur; if any unusual symptoms arise, seek medical attention immediately. This medication may interact with other drugs; those taking blood pressure medications, diuretics, anticoagulants, antidepressants, antibiotics, etc., must inform their healthcare provider, as dose adjustments or monitoring may be necessary. Women who are pregnant or may become pregnant, as well as nursing mothers, should avoid this medication, and women planning pregnancy should exercise caution. Safety in children and adolescents has not been established, so its use is not recommended. Elderly patients may have reduced kidney, liver, and heart function, hence dose adjustments and monitoring are required. Regular blood tests and liver and kidney function tests should be conducted for those taking this medication long-term, and should be discontinued if any abnormal findings occur. In case of overdose, symptoms such as nausea, vomiting, drowsiness, lethargy may appear, and serious issues like gastrointestinal bleeding or renal failure may occur, requiring immediate emergency treatment. This medication should be kept out of reach of children and care should be taken not to transfer it to another container as it may alter quality.

Gastrointestinal bleeding, cardiovascular thromboembolic reaction, myocardial infarction, stroke, upper and lower gastrointestinal perforation, ulcer, bleeding, bronchitis, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, headache, leg cramps, sensory reduction, migraine, neuralgia, neuropathy, dysesthesia, cerebral infarction, aseptic meningitis, ataxia, suicidal thoughts, loss of smell, loss of taste, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylaxis-like reaction, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute kidney injury, hyponatremia, menstrual disorders, chest pain, nausea, constipation, diverticulitis, dysphagia, belching, esophagitis, gastroenteritis, gastrointestinal ulcers, gastroesophageal reflux, gastrointestinal discomfort, gastrointestinal disorders, hemorrhoids, hiatal hernia, melena, dry mouth, stomatitis, retrognathia, exacerbation of gastrointestinal inflammation, angular cheilitis, intestinal obstruction, intestinal perforation, gastrointestinal bleeding, hemorrhagic colitis, esophageal perforation, bowel obstruction, osteitis post-extraction, enteric anastomosis ulcer, melena, glossitis, aphthous stomatitis, oral mucosal blistering, numbness of mouth, oral pain, elevated serum sodium, elevated serum potassium, increased BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, anorexia, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, fracture, tendon rupture, pain in the neck, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, ceruminous gland inflammation, contact dermatitis, injection site reactions, skin nodules, taste distortion, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, elevated serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute kidney injury, interstitial nephritis, hallucinations, hearing loss, ear abnormalities, otalgia, hearing impairment

This medication should be stored in a tightly closed container to prevent air or moisture ingress, and it is best kept in a cool place between 15 and 30 degrees Celsius.

Appearance

White to light yellow powder-filled white hard capsules with blue stripes on the cap and body

Package unit

30 capsules/bottle, 100 capsules/bottle, 300 capsules/bottle