Doperin Tablet 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Adults: Administer 5 mg of Donepezil Hydrochloride once daily before bedtime. For 4 to 6 weeks, the dose should remain at 5 mg, and after evaluating clinical responses, it can be increased up to 10 mg. When increasing the dosage to 10 mg daily, caution should be exercised regarding gastrointestinal adverse reactions. Women over 85 years of age who are underweight should not exceed 5 mg daily and require careful monitoring.

Child dose

Children: There is no experience using this medication in children.

This medication contains Donepezil Hydrochloride Hydrate as its active ingredient, and is used for the treatment of Alzheimer's type dementia symptoms. This medication should not be used by individuals who are hypersensitive to Donepezil Hydrochloride, piperidine derivatives, or any of the components of this medication. Additionally, women who are pregnant or may become pregnant, as well as nursing mothers, should not take this medication. This medication contains lactose, thus patients with hereditary issues such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should also refrain from taking it. Patients with heart diseases or those with bradycardia or atrioventricular block should be cautious when administering this medication, as it may stimulate the vagus nerve, causing bradycardia or arrhythmias. Patients currently taking non-steroidal anti-inflammatory drugs or those with a history of peptic ulcers should be careful, as increased gastric acid secretion may worsen ulcer symptoms. Patients with a history of asthma or obstructive pulmonary disease should be cautious, as bronchial smooth muscle contraction and increased mucus secretion may exacerbate symptoms. Patients with extrapyramidal disorders such as Parkinson’s disease may have their symptoms worsened, so caution is advised. This medication contains the dye Yellow No. 5, and individuals with allergies or hypersensitivity to this component should be cautious. During treatment, symptoms related to the heart such as syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, and heart failure may occur, so if any unusual symptoms arise, immediate consultation with healthcare personnel is required. Severe adverse reactions have been reported, including peptic ulcers, gastrointestinal bleeding, hepatitis, liver dysfunction, convulsions, extrapyramidal symptoms, neuroleptic malignant syndrome, rhabdomyolysis, dyspnea, acute pancreatitis, acute renal failure, and unexplained sudden death, so caution is necessary. This medication can cause various side effects including diarrhea, nausea, vomiting, loss of appetite, dizziness, insomnia, headache, fatigue, myalgia, urinary incontinence, and excessive sweating, many of which are generally mild or transient. A definitive diagnosis of Alzheimer's type dementia must be established before taking this medication, and the therapeutic effects should be periodically evaluated to consider cessation if ineffective. Patients with cardiac conditions or electrolyte imbalances may require regular monitoring such as ECG testing. This medication may impair the ability to drive or operate machinery, so caution should be exercised during the initial phase of treatment or when the dosage is increased. This medication may interact with various other drugs, so patients must inform healthcare providers of any other medications they are taking. It is generally recommended that women who are pregnant or breastfeeding avoid this medication, and if it must be taken, breastfeeding should be discontinued. Safety in children has not been established, therefore this medication should not be used in pediatric patients. In cases of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, convulsions, and respiratory depression may occur, and immediate medical treatment is required; atropine may be used as an antidote. This medication should be stored out of reach of children, and transferring it to other containers may negatively impact its quality.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, shortness of breath, asthma attack, chest tightness, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, markedly decreased urine output, severe swelling of the body and blood pressure

Mild side effects

Loss of appetite, insomnia, drowsiness, headache, dizziness, myalgia, fatigue, nausea, vomiting, diarrhea, abdominal pain, itching, rash, increased blood pressure, anxiety, hallucinations, aggressive behavior, tremor, gait disturbance, involuntary movements, reduced concentration, mental dullness, drowsiness, palpitations, lethargy, sweating, petechiae, urinary incontinence, frequent urination, urination disorders, dehydration, weight loss, edema, changes in blood levels (CK, LDH, AST, ALT,

This medication should be stored in a tightly sealed container to prevent air ingress, ideally at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its efficacy and safety.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle