MediCox Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or divide the dose into 100 mg twice daily. 2. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg per dose twice daily. 3. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg/day. If no effect is observed after 6 weeks at 400 mg/day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day if needed. Starting on the second day, the recommended dose as needed is 200 mg per dose twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may cause gastrointestinal bleeding in those who regularly consume more than three servings of alcohol per day, so consultation with a doctor or pharmacist is essential. This medication can affect the cardiovascular system, increasing the risk of serious thrombotic problems such as myocardial infarction or stroke. Individuals with a history of cardiovascular disease should exercise extra caution and use the minimum effective dose for the shortest duration possible. This medication can also impact the gastrointestinal tract, potentially resulting in serious gastrointestinal issues such as gastric ulcers, bleeding, or perforation. Elderly individuals and those with a history of gastrointestinal diseases should be particularly careful, and should consult medical staff immediately if they experience symptoms such as epigastric pain, indigestion, black stools, or vomiting during treatment. This medication should not be administered to individuals with specific allergic reactions, severe liver or kidney diseases, those with active gastrointestinal bleeding, heart failure patients, or women who are pregnant or breastfeeding. Individuals with impaired liver or kidney function, asthma patients, those with a history of hypertension or cardiovascular disease, and the elderly should consult medical staff carefully before using this medication and have their conditions monitored periodically. Dizziness or drowsiness may occur during treatment, so caution is advised when driving or operating machinery. This medication may interact with other drugs, so consultation with medical staff is especially important when taken alongside antihypertensives, diuretics, anticoagulants, antidepressants, or antineoplastics. Women who are pregnant or planning to become pregnant should discuss the potential effects on fertility with their doctor before taking this medication, and should cease use immediately if pregnancy is confirmed. Those on long-term treatment should undergo regular tests to monitor liver, kidney function, and blood, and should report any unusual symptoms to medical staff immediately. This medication has not been established as safe or effective for children and adolescents, so it is advisable to avoid use in these populations. Elderly patients may have reduced bodily functions, so special caution is required during treatment, and starting with the minimum dose is preferable if body weight is low.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, upper and lower gastrointestinal perforations, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, trauma, headache, leg cramps, muscle tension, sensory disturbance, migraine, neuralgia, neuropathy, paresthesia, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, ageusia, allergic exacerbation, allergic reaction, weakness, chest pain, fluid retention, genital edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reactions, angioedema, decreased appetite, increased appetite, depression, neuro-sensitivity reactions, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory infection, bronchospasm, exacerbated bronchospasm, dyspnea, laryngitis, pneumonia, nosebleeds, voice disorders, vesicular lesions, petechiae, alopecia, inflammation, nail disorders, phototoxic reactions, pruritus, erythematous rash, maculopapular rash, dryness, increased sweating, erythema multiforme, exfoliative dermatitis, mucous membrane syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic inflammation, petechiae, dandruff, drug rash with eosinophilia and systemic symptoms, arrhythmia, left ventricular hypertrophy, angina, unstable angina, coronary artery disorder, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accidents, peripheral necrosis, thrombophlebitis, vasculitis, deep vein thrombosis, cerebral hemorrhage, wounds, gingivitis, herpes simplex, shingles, bacterial infections, fungal infections, soft tissue infections, viral infections, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasms, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, otalgia, hearing impairment, dysfunction, cholelithiasis, jaundice, liver failure, fulminant inflammation, necrosis, elevated serum sodium, elevated serum potassium, increased BUN, elevated CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, elevated LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthrosis, skeletal anomalies, myalgia, cervical dystonia, synovitis, tendonitis, myositis, fractures, tendon ruptures, muscle stiffness, decreased hematocrit, increased hemoglobin, nosebleeds, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic pneumonia, contact dermatitis, injection site reactions, skin nodules, taste disorders, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infections, visual disturbance, cataracts, conjunctivitis, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, anaphylactic reactions, hallucinations, cerebral hemorrhage, loss of taste, loss of smell, conjunctivitis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, phototoxic reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized eruptive pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change glomerulonephritis, menstrual disorders, female infertility, chest pain, lethargy, drowsiness, nausea, upper abdominal pain, gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, coma

This medication must be stored in a tightly closed container to prevent exposure to air or moisture. It is best to maintain storage temperatures between 15 to 30 degrees Celsius.

Appearance

White opaque hard capsule containing white to light yellow powder

Package unit

30 capsules/bottle, 100 capsules/bottle