Tibolone Tablet (Tibolone)

Adult dose

This medication should be taken as one tablet daily at the same time. It is recommended to take the tablet with water or another drink consistently at the same time each day. No dosage adjustment is needed for the elderly.

This medication should absolutely not be administered to pregnant or lactating women. It should not be given to patients with or suspected of having breast cancer, estrogen-dependent malignancies, undiagnosed vaginal bleeding, untreated endometrial hyperplasia, or a history of thromboembolism. Additionally, it should not be used in patients with impaired liver function, allergies to the ingredients of this medication, porphyria, or hereditary lactose intolerance. If liver function worsens or symptoms such as elevated blood pressure or migraines occur during treatment, administration should be discontinued immediately. Close monitoring is necessary for those with a history of uterine fibroids, endometriosis, risk factors for thromboembolism, hypertension, liver disease, diabetes, migraines, systemic lupus erythematosus, epilepsy, asthma, or otosclerosis, as these conditions may worsen. While taking this medication, side effects such as lower abdominal pain, increased body hair, acne, increased vaginal discharge, increased endometrial thickness, postmenopausal bleeding, breast tenderness, vulvar itching, vaginal candidiasis, vaginal bleeding, pelvic pain, cervical dysplasia, weight gain, and others may occur. The risk of breast cancer, endometrial cancer, ischemic stroke, ovarian cancer, venous thromboembolism, and coronary artery disease may increase; therefore, women over 60 should carefully assess the benefits and risks of this medication. This medication can affect blood coagulation, enhancing the effects of anticoagulants, so patients on anticoagulants need dosage adjustments and caution. Additionally, its effects may decrease when combined with drugs that induce certain liver enzymes. It should not be used during pregnancy, and if pregnancy is confirmed, administration should be stopped immediately. It should also not be used while breastfeeding. In case of overdose, symptoms such as nausea, vomiting, and vaginal bleeding may appear, and since there is no specific antidote, appropriate treatment should be administered based on the symptoms. During storage, it should be kept out of reach of children in its original packaging. This medication carries various risks related to female hormones; therefore, regular check-ups and consultation with a physician before and during treatment are essential.

Serious side effects

Headache (migraine type), elevated blood pressure, jaundice, worsening liver function, deep vein thrombosis, pulmonary embolism, arterial thromboembolism, stroke (ischemic stroke), myocardial infarction, endometrial cancer, breast cancer, ovarian cancer, venous thromboembolism, severe swelling, elevated blood pressure, symptoms of thrombosis (painful leg swelling, sudden chest pain, shortness of breath)

Mild side effects

• Lower abdominal pain
• abnormal increase in body hair
• acne
• vaginal discharge
• increased endometrial thickness
• postmenopausal bleeding
• breast discomfort
• vulvar pruritus
• vaginal candidiasis
• vaginal bleeding

This medication should be stored in a sealed container to prevent air exposure and should be kept at a temperature below 25 degrees Celsius to maintain its efficacy over time.

Appearance

White oblong tablet

Package unit

28 tablets (28 tablets/PTP X 1)