Actimmet Tablet 15/850mg

Adult dosage

The dosage of this medication should be individualized based on efficacy and tolerability, not exceeding the maximum dosages of its components, pioglitazone 30mg and metformin 2500mg. The initial dosage should be based on the patient's current treatment regimen. Patients on monotherapy with metformin or pioglitazone should start this medication at 1 tablet once daily, evaluating the treatment response and gradually adjusting the dosage. In the combination therapy of pioglitazone and metformin, preceded by

This medication can cause severe lactic acidosis and hypoglycemia, thus caution is required, especially in patients with impaired renal function or those with heart or lung conditions or sepsis. Lactic acidosis is rare but a very dangerous condition that can occur due to the accumulation of this medication in the body and can be fatal. It is advisable not to administer this medication to patients with liver dysfunction, and excessive acute or chronic alcohol intake should also be avoided. Patients with heart failure or severe cardiac conditions should not use this medication, and if signs of heart failure occur, immediate consultation with medical personnel is necessary. Patients with active bladder cancer or a history of bladder cancer should carefully consider the risks and benefits before using this medication. Women who are pregnant or breastfeeding should not take this medication, and safety in pediatric patients has not been established. Elderly patients may have reduced kidney function, so it is important to adjust the dosage and regularly monitor kidney function. During the course of taking this medication, blood sugar levels, kidney function, liver function, and hematological parameters should be routinely checked, and any abnormal symptoms should be reported to a physician immediately. Additionally, the administration of this medication should be temporarily discontinued before and after surgery or tests using iodine contrast agents, and it should be re-administered only after confirming renal function. This medication may interact with other drugs, so it is crucial to inform the medical staff of any other medications being taken. There is a risk of hypoglycemia due to irregular meals, excessive exercise, or the combination with other hypoglycemic agents, necessitating caution. In case of overdose, appropriate supportive therapy and possibly hemodialysis may be needed; hence, dosages must be strictly adhered to.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in the mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by coughing and fever, jaundice of the skin or eyes, extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, significantly reduced urine output

Mild side effects

• Upper respiratory tract infection
• diarrhea
• nausea
• headache
• urinary tract infection
• sinusitis
• dizziness
• lower limb edema
• weight gain
• myalgia

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. The storage temperature should be maintained at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's effectiveness for a longer duration.

Appearance

White to grayish-white oblong film-coated tablet

Package unit

30 tablets (10 tablets/PTP * 3)