Yugenta Duo Tablet 2.5/1000 mg

Adult dose

The dosage of this drug is determined based on each ingredient's maximum recommended dose of linagliptin 2.5 mg and metformin 1000 mg not exceeding twice daily, considering each patient's current treatment regimen, efficacy, and tolerance. This drug is administered twice daily with meals. 1. If currently not treated with metformin: As an initial dosage, take 2.5/500 mg of this drug twice a day, one tablet at a time.

This drug can cause a rare complication known as lactic acidosis, which is particularly dangerous for patients with impaired renal function or severe heart disease. This drug should not be used if there is an allergy to any ingredient, or if the patient has type 1 diabetes, diabetic ketoacidosis, severe renal impairment, liver dysfunction, acute alcohol intoxication, or certain other diseases. Caution is necessary when used with other blood sugar-lowering medications due to the risk of hypoglycemia, especially when combined with insulin or sulfonylureas, where dose adjustments may be necessary. Patients with reduced kidney function should undergo regular kidney function tests before and during treatment with this drug. Caution is advised in patients with heart disease, such as heart failure or acute myocardial infarction. If an iodine contrast agent is used during radiological examinations, this drug should be discontinued for a certain period before and after the test and can be resumed only after stabilizing kidney function. Acute pancreatitis or blistering skin diseases may occur; if severe abdominal pain or skin abnormalities appear during treatment, consult a physician immediately. This drug can lower vitamin B12 levels; therefore, checking for vitamin B12 deficiency may be necessary during prolonged use. Women who are pregnant or may become pregnant, as well as breastfeeding mothers, are advised not to use this drug and should consult with a physician if planning to become pregnant. The safety in children under 10 years old and teenagers has not been established, and usage is not recommended. Elderly patients may experience reduced kidney function; therefore, regular monitoring of kidney function and starting at the minimum dose is important. In case of overdose, serious adverse effects such as lactic acidosis may occur, requiring immediate medical treatment. This drug should be stored away from moisture and direct sunlight, and kept out of reach of children, and it is advisable not to transfer it into another container.

Serious side effects

• Hives
• angioedema
• lactic acidosis
• pancreatitis
• bullous pemphigoid
• hepatitis
• acute myocardial infarction
• cardiac arrest
• confusion
• seizures

Mild side effects

• Nasopharyngitis
• hypersensitivity
• angioedema
• decreased and deficiency of vitamin B12
• taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This drug is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage helps maintain the drug's efficacy over time.

Appearance

Bright pink, double convex, oval film-coated tablet

Package unit

60 tablets (10 tablets/PTP packaging x 6)