Medication info
Tugenonjeong 5/16 mg

Tugenonjeong 5/16 mg

Prescription medicationTablet경구
Ingredient · strength
Rosuvastatin Calcium›5.2mg / 1 tabletCandesartan Cilexetil›16mg / 1 tablet
Manufacturer / importer
동아에스티(주)
Appearance
Pink round film-coated tablet
Packaging
30 tablets (10 tablets/PTP x 3)
Approval status
Active

MFDS item code 201803501 · Approved 2018.08.28

Summary

Main use
(Hypertension, heart failure) improvement and (hypercholesterolemia, cardiovascular disease risk) prevention
Who takes it
Adults · Children
Adult dose
Candesartan Cilexetil 1. Essential Hypertension - The recommended starting and maintenance dose is 8 to 16 mg orally once daily. - If blood pressure is insufficiently controlled after 4 weeks of treatment at 16 mg once daily, the dose may be increased to a maximum of 32 mg once daily. - The initial dose for patients with intravascular volume depletion and renal impairment is 4 mg, while patients with liver impairment should start at 2 mg. 2.
Child dose
Safety and efficacy have not been established for adolescents and children under 18 years of age.

Ingredients

Manufacturer
동아에스티(주)

Efficacy & effects

(Hypertension, heart failure) improvement and (hypercholesterolemia, cardiovascular disease risk) prevention

  • Essential hypertension
  • left ventricular systolic dysfunction
  • hypercholesterolemia
  • mixed dyslipidemia
  • homozygous familial hypercholesterolemia
  • dysbetalipoproteinemia
  • hypertension
  • low HDL cholesterol levels
  • smoking
  • family history of early coronary artery disease
View approved original text

This medicine is applied to patients using two drugs, Candesartan Cilexetil and Rosuvastatin. Candesartan Cilexetil is mainly used in patients with essential hypertension or heart failure with left ventricular dysfunction, especially when the use of ACE inhibitors is difficult or additional treatment is required. Meanwhile, Rosuvastatin is used as an adjunct to patients with hypercholesterolemia or mixed dyslipidemia when dietary control is not sufficient, and it also helps in the treatment of homozygous familial hypercholesterolemia and dysbetalipoproteinemia. Additionally, Rosuvastatin contributes to reducing the risk of stroke, myocardial infarction, and vascular reintervention in high-risk cardiovascular disease patients. By using both drugs together, cardiovascular health can be effectively improved through the management of blood pressure and blood cholesterol.

How to take

Adult dose

Candesartan Cilexetil 1. Essential Hypertension - The recommended starting and maintenance dose is 8 to 16 mg orally once daily. - If blood pressure is insufficiently controlled after 4 weeks of treatment at 16 mg once daily, the dose may be increased to a maximum of 32 mg once daily. - The initial dose for patients with intravascular volume depletion and renal impairment is 4 mg, while patients with liver impairment should start at 2 mg. 2.

Child dose

Safety and efficacy have not been established for adolescents and children under 18 years of age.

Precautions

This medication may cause serious harm to the fetus and newborn when taken during pregnancy, so it should be discontinued immediately if pregnancy is confirmed. Patients with a known allergy to this medicine or its components should not take it. It should not be administered to patients with severely impaired liver function, active liver disease, or severe kidney disease. Women of childbearing potential should practice appropriate contraception and should only take this medication after fully understanding the risks, even if the likelihood of pregnancy is low. This medication should be used cautiously in the elderly, patients with hyperkalemia, and those with mild to moderate hepatic impairment, requiring regular blood tests and liver function checks. If symptoms of musculoskeletal disorders such as muscle pain or weakness occur, patients should consult a doctor immediately, and in severe cases, treatment should be discontinued. This medicine may interact with other antihypertensive agents, diuretics, certain antibiotics, etc., so patients must inform their doctor or pharmacist about any other medications they are taking. During treatment, excessive alcohol should be avoided, and patients with liver or kidney function abnormalities should have regular check-ups. It is preferable for pregnant or breastfeeding women to avoid using this medicine, and if unavoidable, breastfeeding should be discontinued. Safety and efficacy have not been established for children, so it is not recommended. In case of overdose, symptoms such as hypotension and dizziness may occur, necessitating immediate medical attention. Caution is needed when driving or operating machinery as dizziness due to blood pressure lowering may occur. Keep this medication out of the reach of children, and it is not recommended to transfer medicines from the original container to another.

Side effects and when to seek care immediately

Serious side effects

Hives, angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthmatic attack, respiratory distress accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, markedly decreased urine output

Mild side effects

  • Headache
  • dizziness
  • nasopharyngitis
  • itching
  • generalized itching
  • dyspepsia
  • nausea
  • fatigue
  • inflammation
  • foreign body sensation
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  • joint stiffness
  • limb pain
  • glare
  • increase in blood sugar
  • decrease in serum sodium
  • hand fractures
  • hypoglycemia
  • nephrolithiasis
  • cough
  • extraction
  • constipation
  • abdominal pain
  • diarrhea
  • loss of appetite
  • abdominal distension
  • syncope
  • generalized pain
  • muscle cramps
  • gout
  • erectile dysfunction
  • asthenia
  • arthralgia
  • paresthesia
  • discomfort in the chest

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, avoid extremes in temperature, and it is best to store it at room temperature between 1 and 30 degrees Celsius.

Appearance and packaging

Appearance

Pink round film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.