Secob Capsule 100 Milligrams (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or divide the dose into 100 mg per dose twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg per dose twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment at 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of administration if needed. From the second day onward, the recommended dose as needed is 200 mg per dose twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may increase the risk of gastrointestinal bleeding if taken by individuals who regularly consume more than three drinks per day, and consultation with a doctor or pharmacist is essential. It may increase the risk of cardiovascular events, potentially leading to serious thrombotic events such as myocardial infarction or stroke; therefore, it should be used at the lowest effective dose for the shortest duration necessary. Serious gastrointestinal issues such as ulcers, bleeding, or perforation may occur, especially in elderly patients or those with a history of gastrointestinal disorders, so caution is needed. This drug should not be used in patients with certain allergies, severe liver or kidney dysfunction, active gastrointestinal ulcers, congestive heart failure, pregnant or breastfeeding women. Patients with impaired liver or kidney function, asthma, hypertension, or a history of cardiovascular disease should use it cautiously and strictly follow medical instructions. During use, various adverse reactions such as dyspepsia, abdominal pain, headache, dizziness, skin rash, edema, and heart-related symptoms may occur; report any unusual symptoms immediately to medical personnel. As this medication is metabolized in the liver, it can impact liver function, and regular liver and kidney function tests should be conducted. There are many drug interactions; if you are taking other medications, ensure you inform your healthcare provider, particularly regarding blood pressure medications, anticoagulants, antidepressants, and antibiotics. Women who are pregnant or planning to become pregnant should avoid this medication, and nursing mothers are advised to discontinue either the medication or breastfeeding. Elderly patients may have a higher risk of decreased kidney and heart function; therefore, careful observation is necessary during administration. While taking this medicine, care should be taken when driving or operating machinery, as dizziness or drowsiness may occur. In cases of overdose, symptoms such as nausea, vomiting, drowsiness, and gastrointestinal bleeding may appear, and immediate medical attention should be sought.

Gastrointestinal bleeding, cardiovascular thrombotic events, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, dysgeusia, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased blood creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal impairment, acute kidney injury, interstitial nephritis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, decreased appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthrosis, skeletal deformities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in various areas, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic inflammation, contact dermatitis, injection site reactions, skin nodules, chest pain, headache, dizziness, constipation, thirst, ulcerative stomatitis, gastritis, allergies, low back pain, hyperlipidemia, pneumonia, dyspnea, hearing loss, anaphylaxis, hallucinations, cerebral hemorrhage, aseptic meningitis, taste loss, smell loss, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute kidney injury, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change glomerulonephritis, menstrual disorders, female infertility

Store this medication in a tightly sealed container to prevent air or moisture from entering. It is best to keep it at a moderate temperature between 15 to 30 degrees Celsius, away from extreme heat or cold.

Appearance

A capsule filled with white to pale yellow powder, with both the upper and lower parts being white.

Package unit

30 capsules/bottle, 100 capsules/bottle