Donepezil 10 mg Tablets (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. After 15 days, normal condition is reached, so maintain the 5 mg dose for 4-6 weeks. After evaluating clinical response, the dose can be increased up to 10 mg. If increasing to 10 mg daily, administer while paying attention to gastrointestinal adverse reactions. Underweight elderly women should not exceed 5 mg daily.

Child dose

There is no experience in using this medication in children.

This medication contains Donepezil Hydrochloride Hydrate as its active ingredient and is used for the treatment of Alzheimer's type dementia symptoms. This medication should not be administered to individuals who are allergic to Donepezil Hydrochloride or any components of this medication, to pregnant women or women who may become pregnant, and to lactating women. Patients with heart conditions or conduction disorders should use this medication cautiously as it may slow heart rate or cause arrhythmia. Those taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be cautious as this medication may increase gastric acid secretion and promote gastrointestinal motility, potentially worsening symptoms. Patients with a history of asthma or obstructive pulmonary disease should be careful in administering this medication, as it may cause bronchial muscle contraction and increase mucus secretion, worsening symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should be cautious, as this medication may affect the nervous system and worsen symptoms. Serious side effects such as fainting, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, cerebrovascular accidents, movement disorders, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and sudden death may occur during the use of this medication; if any abnormal symptoms occur, immediate consultation with a physician is advised. Additionally, various side effects such as dizziness, nausea, vomiting, diarrhea, insomnia, hallucinations, anxiety, muscle pain, fatigue have been reported; if these symptoms persist or worsen while taking this medication, it is necessary to seek professional medical care. The use of this medication is not approved for other forms of memory disorders besides dementia, and treatment must be conducted under the supervision of an experienced physician. Patients with heart disease or electrolyte abnormalities should undergo regular ECG tests while taking this medication, and caution is necessary when driving or operating machinery. Since this medication is metabolized in the liver, patients with reduced liver function may require dosage adjustment or monitoring. It is advisable for pregnant or lactating women not to use this medication, and if unavoidable, they should consult with a professional before use. This medication may interact with other drugs; caution is especially needed when used in combination with drugs that affect CYP3A4 or CYP2D6 enzymes, drugs affecting cardiac conduction, anticholinergic drugs, and cholinergic drugs. In case of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and convulsions may occur, and immediate medical treatment is required. Keep out of reach of children and do not transfer medication to other containers as it is important for quality maintenance.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain (severe dermatological adverse reactions), shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy (liver abnormalities), sudden and severe headache,

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• tremor
• gait disturbance

This medication should be stored in an airtight container that is well-ventilated, at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a long time.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle