Newdon Pilsu Tablets 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, the 5 mg dose should be administered. After evaluating the clinical response during this period, the dose can be increased to 10 mg. When increasing to 10 mg per day, caution should be exercised for gastrointestinal adverse reactions. Underweight women over 85 years should not exceed 5 mg per day.

Child dose

There is no experience in pediatric use.

This medication should not be used by individuals who are allergic to certain ingredients, pregnant or nursing women, or patients with genetic lactose intolerance. Patients with heart disease or a history of peptic ulcers, asthma or obstructive pulmonary disease, and those with extrapyramidal disorders such as Parkinson's disease should exercise special caution when using this medication. It may slow heart rate or cause arrhythmias and has the risk of worsening gastrointestinal bleeding or ulcers, so changes in symptoms need to be monitored closely. Additionally, serious side effects such as liver dysfunction, cerebrovascular issues, muscle abnormalities, respiratory distress, acute pancreatitis, and renal failure may occur, and if any unusual symptoms arise, immediate consultation with healthcare professionals is required. This drug can affect driving or machine operation ability, so caution is necessary at the beginning of treatment or during dosage adjustments. Pregnant or nursing women are advised not to take this medication and should consult a professional in case of necessity. This medication may interact with other drugs, especially those affecting liver metabolism or cardiovascular drugs, and caution should be taken in such cases. In case of overdose, severe nausea, vomiting, muscle weakness, and respiratory distress may occur, requiring immediate medical attention.

Serious side effects

Syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcer, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizure, epilepsy, convulsions, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (motor dysfunction, ataxia, movement disorders, dystonia, tremor, involuntary movement, gait disturbance, abnormal posture, speech impairment), neuroleptic malignant syndrome (akinetic mutism, severe muscle rigidity)

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• drowsiness
• sweating

This medication should be stored in a sealed container to prevent exposure to air and moisture, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius. This helps maintain the medication's effectiveness over time.

Appearance

Dark yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle