Osheal Injection (Sodium Hyaluronate)

Adult administration

Typically, for adults, 1 vial is administered once a week for 3 consecutive weeks into the knee joint or shoulder joint (intra-articular space, subacromial bursa, or tendon sheath of the biceps). The frequency of administration should be adjusted based on symptoms.

This medication should not be used in patients who have previously experienced allergic reactions to any of its ingredients. Precautions should also be taken for patients who have had allergic reactions to other medications or who have liver dysfunction or a history of liver disease. Since this medication is administered intra-articularly, it should be used cautiously in patients with skin diseases or infections at the injection site. Serious allergic reactions may occur during use; therefore, if sudden shock symptoms manifest, administration should be immediately discontinued and appropriate medical treatment sought. Additionally, if symptoms of allergy such as swelling of the face or around the eyes, rashes, or itching appear, use should be stopped, and medical help obtained. Transient pain or swelling, redness, or warmth may occur at the injected joint site, and these symptoms should be reported to healthcare professionals. Occasionally, symptoms such as nausea, vomiting, or fever may also occur, so caution is warranted. Injecting this medication into inflamed joints may exacerbate inflammation; therefore, it is advisable to use it after inflammation has subsided. After administration, stabilizing the injection site is recommended, and it is important to ensure that the drug does not leak outside the joint. Injections should be performed under strictly aseptic conditions, and if symptoms do not improve, administration should be discontinued after three applications. If there is fluid accumulation in the joint, it is advisable to drain the fluid before administration, if necessary. This medication should not be injected directly into blood vessels or the eyes, and appropriate injection needles must be used. Furthermore, caution should be exercised as the drug may precipitate when used with certain disinfectants. For women who are pregnant or may become pregnant, this medication should only be used cautiously when the benefits outweigh the risks. During breastfeeding, it is advisable to avoid breastfeeding as the drug may be transmitted through breast milk. Safety has not been fully established in children; therefore, it should only be used cautiously in necessary situations. Elderly individuals may have decreased bodily functions, so extra caution is needed during use.

Serious side effects

Shock symptoms

Mild side effects

Edema (facial, eyelid, etc.), facial flushing, rash, urticaria, itching, pain (mainly transient pain after administration), swelling, edema, redness, warmth, severe localized pressure sensation, nausea, vomiting, fever

This medication should be stored in a sealed container to prevent air or moisture ingress. It is important to maintain the storage temperature between 1 degree and 30 degrees Celsius.

Appearance

A colorless transparent viscous liquid filled in a colorless transparent vial sealed with rubber stoppers at both ends, part of a prefilled syringe system.

Package unit

2.0 milliliters (1 vial) x 3 vials