Ysept 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, taking this drug in the morning may be considered. Since donepezil concentrations reach steady state 15 days after administration and the incidence of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. If this drug is discontinued, its effects gradually diminish, and no rebound effect occurs following abrupt discontinuation. ○ Female patients aged 85 years or older who are underweight: Because adverse reactions occur more frequently, careful monitoring is required. Elderly women who are underweight should not exceed 5 mg daily.

Child dose

○ Children: There is no experience with use in children.

This medication is used for the improvement of Alzheimer's disease symptoms with the active ingredient donepezil hydrochloride. First, this medication should not be used by individuals allergic to this active ingredient or similar medications, women who are pregnant or may become pregnant, and women who are breastfeeding. Patients with heart disease should take caution as this medication may slow heart rate or induce arrhythmia. Additionally, those with peptic ulcers or taking non-steroidal anti-inflammatory drugs should be careful due to the risk of gastrointestinal bleeding. Patients with a history of asthma or chronic obstructive pulmonary disease may experience exacerbation of symptoms due to bronchoconstriction caused by this medication. Patients with extrapyramidal disorders, such as Parkinson's disease, should also use this medication cautiously as their symptoms may worsen. This medication contains Yellow No. 5 dye, hence individuals allergic to this dye should exercise caution. Side effects may include fainting, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, seizures, movement disorders, respiratory distress, acute pancreatitis, and renal failure, albeit rarely. If any unusual symptoms arise, consult a healthcare professional immediately. This medication can assist in improving dementia symptoms, but the treatment effects should be regularly evaluated and discontinuation should be considered if necessary. Patients with heart disease or electrolyte imbalances may require an electrocardiogram due to the risk of arrhythmia. Caution should be exercised when driving or operating machinery as dizziness or fatigue may occur, particularly at the beginning of treatment or after a dose change. This medication may interact with multiple other drugs, therefore individuals taking other medications should consult their doctor or pharmacist. Pregnant or breastfeeding women should avoid using this medication unless absolutely necessary and should consult with a professional beforehand. Safety in pediatric patients has not been established, therefore it is not used in children. In cases of overdose, severe side effects such as vomiting, bradycardia, and respiratory depression may occur; immediate medical attention is required, and atropine may be used as an antidote. Finally, this medication should be kept out of reach of children and should not be transferred to other containers.

• Syncope
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it is safest to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the medication's effectiveness for a longer period.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle