Boryung Hemosis VL Solution (Sodium Bicarbonate)

Adult dosage

When using the defined acetate-containing dialysis solution (Solution A), this preparation can create a sodium bicarbonate-based dialysis solution containing HCO3- at 35 mEq/L. It is used as dialysis fluid in hemodialysis when using a dilution ratio of 1:1.225:32.775 of acetate-containing dialysis solution (Solution A), this preparation, and purified water.

This medication should not be used in patients with low blood pressure and rapid heart rate. It should also be avoided in patients with pulmonary edema or severe changes in electrocardiogram. Patients with high serum potassium levels and those with blood clotting issues should not be administered this medication. Caution should be exercised when using this medication in patients with severe liver impairment or those who have metabolic issues due to diabetes. Patients taking digitalis preparations should be careful as this medication may decrease serum potassium levels, increasing the risk of drug toxicity. Patients with high serum calcium and phosphorus levels before dialysis should also use this medication with caution. Inadequate calorie intake or diet restrictions due to diabetes may lead to hypoglycemia, thus requiring attention. When using this medication, hypoglycemic symptoms may occur, so appropriate measures such as glucose injection or sugar supply should be taken if symptoms arise. Since serum calcium levels may increase, dialysis solutions should be adjusted if hypercalcemia is suspected. Osteoporosis or osteomalacia-related complications may occur, so appropriate treatment such as vitamin D3 supplementation is necessary. Abnormal calcium deposition may happen, so maintaining serum phosphorus levels within the normal range is crucial. During dialysis, symptoms such as headache, nausea, vomiting, convulsions, and altered consciousness may present, hence dialysis intensity should be adjusted in these cases. It can influence the circulatory system, potentially causing symptoms of hypotension or shock, which necessitates stopping or adjusting dialysis and receiving appropriate treatment if symptoms appear. This medication is used in dialysis for patients with chronic renal failure and is suitable when it is difficult to improve metabolic acidosis, or when hypotension or dialysis disequilibrium syndrome occurs. It is also used for patients who find it difficult to control hyperglycemia due to glucose metabolism abnormalities. During use, it is advisable to regularly check electrolytes, acid-base balance, and blood sugar via blood tests. Pregnant women or those who may become pregnant should only use this medication if the therapeutic benefits outweigh the risks, as its safety has not been established. Safety in children has not been sufficiently confirmed, so caution is necessary. Elderly patients are at risk of bone complications when using this medication; therefore, regular check-ups and management such as vitamin D3 supplementation are required. Dialysis diluent water should be clean water that has undergone appropriate purification processes, and care should be taken regarding dialysis membrane damage and bleeding tendencies. When preparing, do not directly mix this medication with the electrolyte solution for artificial renal dialysis, and it should be accurately prepared with the specified diluent. If the dilution concentration is too high or low, side effects such as headache, abnormal blood pressure, and altered consciousness may occur, necessitating care. It is essential to confirm the electrolyte concentration and pH of the dialysis solution before use. This medication should not be used for injections or peritoneal dialysis, and the prepared dialysis solution should be used immediately. It is safe to use the dialysis solution adjusted to body temperature.

Mild side effects

• Hypoglycemia
• hypercalcemia
• osteoporosis
• osteomalacia
• fibrous osteitis
• ectopic calcification
• headache
• nausea
• vomiting
• convulsions

This medication should be stored in a sealed container to prevent exposure to air and moisture, ideally at room temperature between 1 to 30 degrees Celsius. Storing it this way helps to preserve the efficacy of the medication for a longer duration and prevents degradation.

Appearance

A colorless, transparent liquid filled in a plastic container

Package unit

6.3L per container