Pioglitazone Metformin Tablets 15/850 mg

Adult dosage

The dosage of this medication should be individualized based on the efficacy and tolerability, without exceeding the maximum doses of pioglitazone 30 mg and metformin 2500 mg. The initial dosage should be based on the patient's current treatment regimen, starting with 1 tablet per day for patients on metformin or pioglitazone monotherapy, and adjusting based on therapeutic response. Patients transitioning from pioglitazone and metformin combination therapy should start based on previously prescribed doses.

This medication is used to lower blood sugar and is primarily prescribed for the treatment of type 2 diabetes. During treatment with this medication, renal function is critical; therefore, patients with severely impaired renal function should not use this medication. Moreover, patients with severe heart failure should not take this medication. It is also recommended that patients with compromised liver function avoid using this medication. This medication can cause lactic acidosis, a serious side effect, under conditions such as hypoxia, dehydration, and sepsis, so if such symptoms occur, use should be discontinued immediately. Excessive alcohol consumption is also dangerous, so it is advisable to avoid drinking alcohol while on this medication. This medication should be used cautiously in patients with a history of bladder cancer, and if bladder-related symptoms appear, the physician should be notified immediately. It is advised that pregnant or breastfeeding women do not take this medication. Additionally, safety and efficacy have not been established for children, so this medication is not used in pediatric patients. Elderly patients may have reduced kidney function, so careful dosage adjustment and regular kidney function monitoring are necessary. During the course of this medication, hypoglycemia may occur, so patients should be cautious when skipping meals or engaging in vigorous exercise. In the event of an overdose, immediate medical attention should be sought to receive appropriate treatment, which may include hemodialysis. Finally, this medication may interact with several other drugs, so it is essential to inform the physician or pharmacist of any medications being taken concurrently.

Serious side effects

• Severe lactic acidosis
• hypoglycemia
• death due to lactic acidosis
• acute renal failure
• cardiopulmonary disease
• sepsis
• hypoxia
• jaundice due to liver impairment
• acute liver failure
• congestive heart failure

Mild side effects

• Upper respiratory infection
• diarrhea
• nausea
• headache
• urinary tract infection
• sinusitis
• dizziness
• lower extremity edema
• weight gain
• myalgia

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is room temperature between 1 and 30 degrees Celsius. Proper storage can help maintain the effectiveness of the medication for an extended period.

Appearance

White to off-white oval film-coated tablets

Package unit

30 tablets (10 tablets/PTP × 3)