Nextosmet 15/850 mg Tablets

Adult dosage

The initial dosage of this medication should be based on the patient's current therapy. Patients whose blood sugar is not adequately controlled with metformin or pioglitazone monotherapy should base their dosage on the currently prescribed amount of metformin or pioglitazone. The usual initial dosage is one tablet once daily, with gradual dosage adjustments based on treatment response. Patients transitioning from a combination therapy of pioglitazone and metformin to this medication may start at the existing dosages of pioglitazone and metformin.

This medication is used to treat diabetes and helps control blood sugar. However, it may cause a rare side effect known as severe lactic acidosis, which requires caution. Lactic acidosis is a serious condition caused by excessive accumulation of lactic acid in the body, with symptoms including malaise, muscle pain, difficulty breathing, and abdominal pain. If such symptoms occur, immediately inform a physician and discontinue use of this medication. Additionally, this medication may be risky for patients with impaired kidney or liver function, therefore kidney and liver function tests must be conducted prior to use. Especially, patients with reduced kidney function or severe heart failure should not take this medication. During the course of taking this medication, excessive alcohol consumption should be avoided, and use may be temporarily discontinued in cases of dehydration, serious infection, or around the time of surgery. Furthermore, this medication may cause weight gain, edema, or worsening of heart failure in some patients, so patients should consult their doctor if these symptoms arise. Pregnant or breastfeeding women and children are not recommended to use this medication. While taking this medication, it is essential to regularly check health status through blood sugar, kidney function, liver function, and blood tests, as vitamin B12 deficiency may occur and periodic testing is required. Finally, this medication can interact with other drugs, so any other medications being taken must be reported to a physician or pharmacist. Caution is especially needed when taken with heart medications, diuretics, or antibiotics.

Serious side effects

• Severe lactic acidosis
• hypoglycemia
• congestive heart failure
• angioedema
• liver failure
• liver abnormalities (jaundice)
• severe edema
• severe allergic reactions
• severe skin adverse reactions
• respiratory issues

Mild side effects

• Upper respiratory infection
• diarrhea
• nausea
• headache
• urinary tract infection
• sinusitis
• dizziness
• lower extremity edema
• weight gain
• muscle pain

This medication is sensitive to air and moisture, so it should be stored in a sealed container. Also, to ensure safe use, it is important to store it at room temperature, specifically between 1℃ and 30℃.

Appearance

White to grayish-white oblong film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)