Glimeprex 4 mg (Gliclazide)

Adult dose

Adjusted individually for each patient. Swallow whole without chewing with more than 1/2 cup of water. This medication is taken orally once a day, before breakfast or immediately before the first meal. For patients who have not previously received medications, start treatment with 1 mg of gliclazide. If necessary, increase the dose by 1 mg at intervals of 1 to 2 weeks. Generally, doses over 4 mg show little additional effect.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or those in a comatose state. It should not be administered in cases of allergy to this drug or its ingredients, or to sulfonylureas. There is no experience with this medication in patients with severely impaired liver or kidney function, and it is recommended to switch to insulin therapy in such cases. It is safest for women who are pregnant, possibly pregnant, or breastfeeding to avoid this medication. In cases of severe infections, pre- and post-operative conditions, or severe trauma, insulin therapy may be required, thus this medication should be avoided. Caution is needed in cases of gastrointestinal disturbances like diarrhea or vomiting as this can lead to improper food absorption and increase the risk of hypoglycemia. This medication contains lactose and should not be used in patients with hereditary conditions of lactose intolerance or galactose intolerance. During initial treatment, the risk of hypoglycemia is high, necessitating careful monitoring of blood sugar fluctuations, especially in the elderly, patients with poor nutritional status or irregular eating habits, unbalanced physical activity and carbohydrate intake, alcohol consumers, and those with impaired liver or kidney function. This medication can cause hypoglycemia, with symptoms such as headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness; immediate ingestion of sugar is required if symptoms occur. During initial administration or dosage changes, temporary visual disturbances such as blurred vision or gastrointestinal symptoms may occur. Rarely, liver function abnormalities, blood disorders, or allergic reactions may occur; report any unusual symptoms to a physician immediately. Regular meals, exercise, and weight maintenance are essential while taking this medication, and blood sugar control should be monitored consistently. If hypoglycemia occurs, immediate consumption of sugar is necessary, and it is advisable to carry sugary beverages or snacks at all times. Co-administration with other medications could affect blood sugar control, so inform your doctor or pharmacist about other medications you are taking. In cases of pregnancy or breastfeeding, it is safer to switch to insulin therapy rather than use this medication. Safety and efficacy in individuals under 18 years have not been established, thus it is not used in children. Elderly patients may have reduced kidney function, so dosage adjustments should be carefully considered. In case of overdose, severe hypoglycemia may occur; seek emergency treatment immediately if symptoms are severe. This medication should be stored out of reach of children and kept in its original container.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, hypotension, shock, severe rashes with fever, blisters, skin peeling, mucosal pain in the mouth/eyes, liver function abnormalities (jaundice), severe thrombocytopenia with thrombocytopenic purpura, anaphylaxis, angioedema, skin and mucous membrane syndrome (Stevens-Johnson syndrome), seizures, loss of consciousness, coma, severe headache, convulsions.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggressiveness
• decreased concentration
• reduced agility or motivation

Store this medication in a tightly closed container to protect it from air or moisture. It is best kept at room temperature, between 1 degree and 30 degrees Celsius, avoiding very hot or cold conditions.

Appearance

Pale blue rectangular tablet

Package unit

30 tablets/bottle, 100 tablets/bottle