Donepezil Tablets 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

For Donepezil Hydrochloride, administer 5 mg once daily before bedtime. Administer a dose of 5 mg for 4 to 6 weeks. After evaluating the clinical response, it can be increased to 10 mg. When increasing the daily dosage to 10 mg, it should be administered with caution regarding gastrointestinal side effects. Underweight elderly women should not exceed 5 mg daily.

Child dose

There is no experience regarding the use in pediatric patients.

This medication contains Donepezil Hydrochloride as its active ingredient and is used for the treatment of Alzheimer's-type dementia symptoms. Firstly, this medication should not be used by patients allergic to Donepezil Hydrochloride or any of its components, by women who are pregnant or may become pregnant, and by breastfeeding women. Patients with heart diseases or conduction disorders should be cautious when using this medication and require medical supervision, as it may cause problems such as bradycardia or arrhythmia. Additionally, patients with a history of peptic ulcer or those taking non-steroidal anti-inflammatory drugs should be cautious due to the risk of gastrointestinal bleeding or exacerbation of ulcers. Patients with asthma or chronic obstructive pulmonary disease should also be careful, as use of this medication may worsen symptoms due to bronchoconstriction and increased mucus secretion. Patients with extrapyramidal disorders such as Parkinson's disease should use this medication with caution, as it may worsen symptoms. This drug has been reported to cause serious adverse reactions such as fainting, heart block, myocardial infarction, gastrointestinal bleeding, liver dysfunction, cerebrovascular issues, movement disorders, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and sudden death; if any symptoms occur, medical attention should be sought immediately. Common side effects may include nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, headache, and fatigue. This medication may cause cardiac arrhythmia or prolong the QT interval; therefore, patients with heart disease or those taking QT-prolonging medications require regular electrocardiograms. Pregnant or breastfeeding women are advised not to use this medication unless absolutely necessary, and they should consult a healthcare professional before use. Safety in children has not been established, so it should not be used in pediatric patients. This medication can interact with other drugs, especially those affecting CYP3A4 or CYP2D6 enzymes, muscle relaxants, cholinergic drugs, anticholinergic drugs, antiarrhythmics, certain antibiotics, and antidepressants; patients should definitely inform their healthcare provider. Care should be taken as this medication may affect the ability to drive or operate machinery, and fatigue, dizziness, or muscle cramps may occur during the initial stages of treatment or when changing doses. In cases of overdose, symptoms such as nausea, vomiting, bradycardia, respiratory depression, and seizures may occur, necessitating immediate emergency treatment, and atropine may be used as an antidote. Finally, this medication should be kept out of the reach of children and should not be transferred to other containers.

Serious side effects

Fainting, bradycardia, heart block, prolonged QT interval, myocardial infarction, heart failure, asthma attack, respiratory distress, gastrointestinal bleeding, peptic ulcer, hepatitis, liver dysfunction, jaundice, seizures, convulsions, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (including movement disorders, ataxia, tremors), neuroleptic malignant syndrome (stupor, extreme rigidity, difficulty swallowing, tachycardia, blood pressure fluctuations, sweating, fever accompanying), rhabdomyolysis (muscle pain,

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• drowsiness
• tremors

This medication should be stored in a tightly sealed container to prevent air ingress. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Doing so will help safely preserve the medication's effectiveness.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle