Paliperidone Tablets 4 mg

Adult dose

Adults: Administer 4mg per dose orally twice daily after meals, and increase the dose gradually. The maintenance dose is 8∼16mg daily, divided into 2 doses taken after meals. As absorption of this medicine is easily affected by food, be sure to take it after meals. Carefully monitor each patient and adjust the dose to the minimum required; do not exceed the maximum daily dose of 24mg.

This medication should be used with great caution in elderly patients who have psychotic symptoms related to dementia, as there may be an increased risk of mortality. The risk of cerebrovascular events may be elevated in patients with dementia, so those with risk factors for stroke should be more cautious with its use. There is a risk of venous thromboembolism, so it is crucial to confirm if there are risk factors for thromboembolism and take preventive measures. Patients in a coma or taking strong central nervous system depressants should not use this medication. Drug interactions may occur if taken with specific antifungal agents or HIV medications, therefore concurrent use should be avoided. Patients with lactose intolerance or related genetic disorders should also not take this medication. Individuals with suspected cardiovascular diseases or hypotension should be careful as blood pressure may temporarily drop. Patients with Parkinson's disease or Lewy body dementia should use it cautiously as symptoms may worsen. If there are seizure disorders like epilepsy, there may be an increased risk of seizures, so care should be taken. Those with thoughts of suicide or a history of attempts should consult with a doctor as symptoms may worsen. Patients with impaired liver function may have increased drug levels requiring dosage adjustment and monitoring. Patients with diabetes or risk factors for diabetes may experience elevated blood glucose levels, necessitating frequent monitoring of blood sugar levels. Women who are pregnant or breastfeeding should avoid use or consult a specialist as it may affect the fetus or newborn. This medication can cause drowsiness or decreased concentration, so caution is needed when driving or operating hazardous machinery. If any abnormal symptoms or discomfort occur during medication use, it is crucial to consult healthcare professionals immediately. It is advisable to take this medication after meals, as taking it on an empty stomach may reduce its efficacy. Due to the possibility of interactions with other medications, it is essential to inform healthcare professionals if taking other drugs. Especially since it is metabolized in the liver, caution is needed when used with drugs that inhibit or induce CYP3A4 enzymes.

Tremor, akinesia, excessive saliva production, Parkinson's syndrome, inability to sit still, insomnia, increased prolactin, movement disorders, drowsiness, anxiety, restlessness, irritability, neuroleptic malignant syndrome, catatonic mutism, severe muscle rigidity, dysphagia, tachycardia, blood pressure variations, sweating, consciousness disturbance, respiratory distress, circulatory collapse, dehydration, acute renal failure, tardive dyskinesia, involuntary muscle movements around the mouth, paralytic ileus, appetite loss, nausea, vomiting, severe diarrhea, abdominal distension, lethargy, syndrome of inappropriate antidiuretic hormone secretion, hyponatremia, hypotonicity, urinary sodium hyperexcretion, high urine output, convulsions, rhabdomyolysis, myalgia, sensation of weakness, elevated CK, elevated serum myoglobin, elevated urinary myoglobin, agranulocytosis, leukopenia, liver dysfunction, elevated AST, elevated ALT, elevated γ-GTP, elevated ALP, elevated bilirubin, hyperglycemia, diabetic ketoacidosis, diabetic coma, eosinophilia, rash, eczema, itching, hypotension, orthostatic hypotension, hypertension, electrocardiogram abnormalities, tachycardia, bradycardia, arrhythmia, ventricular extrasystole, loss of controls extrasystoles, palpitations, decreased heart rate, symptoms of Parkinson's syndrome, abnormal muscle tone, control disorders, blurred vision, constipation, decreased appetite, increased appetite, diarrhea, epigastric pain, abdominal pain, gastrointestinal disorders, cheilitis, menstrual irregularities, galactorrhea, ejaculation disorders, gynecomastia, erectile dysfunction, dysuria, urinary retention, urinary incontinence, increased frequency of urination, dizziness, vertigo, dull headache, headache, excitement, over-sedation, over-inhibition, depression, hallucinations, hearing voices, delusions, paranoid delusions, sleep disorders, abnormal behavior, hyperactivity, abnormal brain waves, manic state, consciousness disturbance, emotional disturbances, speech disorders, excessive talkativeness, tension, convulsions, leukocytosis, neutrophilia, lymphocytopenia, erythrocytosis, anemia, erythropenia, reduced hemoglobin, reduced hematocrit, thrombocytosis, thrombocytopenia, atypical lymphocytes, general fatigue, thirst, sensation of weakness, edema, water intoxication, hair loss, sweating, fever, weight gain, weight loss, chest pain, cough, facial edema, aspiration pneumonia, hypothermia, elevated CK, increased triglycerides, elevated serum cholesterol, increased serum insulin, increased serum phospholipids, increased blood sugar, elevated BUN, decreased serum total protein, increased serum potassium, decreased serum potassium, decreased serum sodium, positive urinary protein, positive urinary urobilinogen, positive urinary glucose, thromboembolism, epidermal necrolysis, lethargy

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain the storage temperature between 1 and 30 degrees Celsius.

Appearance

White round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle