Azaprine 25 mg (Azathioprine)

Adult dose

After kidney transplantation: Administer azathioprine orally at an initial dose of 3-5mg/kg body weight per day, with a maintenance dose of 0.5-2mg/kg body weight. For creatinine clearance of 20mL/min or less, the dose should not exceed 1.5mg/kg body weight per day. Autoimmune diseases: For treatment of diseases other than chronic active arthritis, administer 2.0-2.5mg/kg body weight per day. For treatment of chronic active arthritis, administer 1.0-1.5mg/kg body weight per day. Tolerated and effective doses vary among patients; therefore, the dose should be carefully adjusted to achieve the optimal therapeutic effect. Consider discontinuing treatment if the condition has not improved after 12 weeks. Adjust the dose appropriately according to age and symptoms.

This medication should not be used in certain patients. Patients who are allergic or hypersensitive to this medication or related drugs, patients with severe liver disease, kidney disease, or bone marrow disease should not take this medication. Women who are pregnant or may become pregnant, as well as breastfeeding women, should also avoid this medication. Furthermore, patients with genetic lactose intolerance or certain enzyme deficiencies should avoid administration. This medication should be used with caution in patients with weakened bone marrow function or infections. Patients with compromised liver or kidney function, bleeding tendencies, varicella, and those taking certain medications may require dose adjustment or special monitoring. The use of this medication may increase the risk of infections, and there is a possibility of severe infections or tumor occurrence. Regular check-ups are essential as side effects such as decreased blood cell count, liver function abnormalities, pancreatitis, skin rashes, hair loss, pneumonia, and others may arise. During treatment, regular blood tests and monitoring of liver and kidney function should be performed to detect abnormal signs early and respond accordingly. Caution is necessary during long-term use as the risk of side effects may increase. This medication may interact with other drugs, so it is crucial to inform healthcare professionals about any medications being taken. Particularly, caution should be exercised when taking it with immunosuppressants, anticoagulants, specific antibiotics, and medications affecting liver function. This medication should not be used during pregnancy or breastfeeding as it may harm the fetus or newborn. If absolutely necessary, consult healthcare professionals and discontinue breastfeeding. The safety and efficacy of this medication have not been fully established in children or the elderly, and the elderly should be carefully monitored for kidney and liver function. In case of overdose, severe side effects such as nausea, vomiting, diarrhea, decreased blood cell count, and liver function abnormalities may occur, and immediate medical attention is necessary. Keep this medication out of reach of children and store it in its original container. Due to the risk of mutagenicity and carcinogenicity, regular examinations and caution are needed during long-term use.

• Infection
• progressive non-Hodgkin lymphoma
• skin cancer
• sarcoma
• hepatic and splenic T-cell lymphoma
• bone marrow dysfunction
• leukopenia
• thrombocytopenia
• anemia
• agranulocytosis

This medication is sensitive to air and moisture, so it must be stored in a sealed container. It is also important to avoid direct sunlight and keep it in a cool, dry room at a temperature between 1°C and 30°C.

Appearance

Pale yellow round tablet

Package unit

100 tablets/foil [10 tablets x 10]