Dexidifen Syrup (Dexibuprofen)

Adult dose

For patients aged 12 and older, the dosage varies between 7 to 25 mL based on weight, with the maximum daily dosage limited to 72 to 100 mL. For example, for those aged 12 and over weighing over 43kg, the single dosage can be 18–25 mL (215–300 mg), with a maximum daily dosage of 72–100 mL (860–1200 mg).

Child dose

Children over 6 months of age may take 0.4–0.6 mL/kg (5–7 mg/kg of dexibuprofen) once every 4–6 hours as needed, with a maximum of 4 times per day (not exceeding 28 mg/kg).

This medication can cause gastrointestinal bleeding in regular drinkers of more than three glasses of alcohol per day; therefore, it is essential to consult a doctor or pharmacist. As a non-steroidal anti-inflammatory drug, it may increase the risk of cardiovascular diseases, so patients with heart diseases or hypertension should use it with caution. It can cause serious gastrointestinal issues such as gastrointestinal bleeding, ulcers, and perforations; therefore, patients with a history of gastrointestinal disorders should take it particularly carefully. Patients with peptic ulcers, severe liver or kidney dysfunction, severe heart failure, hypertension, or allergies to any components of this medication should not use it. Patients who have previously had allergic reactions to asthma or non-steroidal anti-inflammatory drugs like aspirin should also avoid taking this medication. Those with blood disorders, liver function impairment, kidney function decline, cardiovascular diseases, and elderly individuals require extra caution while using this medication and should consult medical personnel immediately if symptoms occur. Taking this medication with aspirin can reduce aspirin's heart-protective effects and increase the risk of gastrointestinal bleeding; thus, concomitant use is not recommended. Serious allergic reactions such as skin rashes, difficulty breathing, and hypotension may occur while taking this medication; if such symptoms appear, discontinue use immediately and consult a doctor. Especially in late pregnancy, it can harm the fetus, so it is safer for pregnant women not to use this medication. Nursing women should also avoid taking this medication, as it can be transmitted through breast milk and may cause adverse reactions in infants. Children and elderly patients are more sensitive to adverse effects; therefore, they should use the minimum dose cautiously and should be regularly monitored by a physician during treatment. This medication may interact with other non-steroidal anti-inflammatory drugs, antihypertensive drugs, anticoagulants, etc., so it is vital to inform your doctor of any medications you are currently taking. In case of overdose, immediate emergency treatment such as gastric lavage or inducing vomiting should be sought, and it should be stored safely out of reach of children.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, asthma attack, cold sweat, pallor, severe allergic reaction, high fever accompanied by severe rashes, blisters, skin peeling, pain in oral/eye mucous membranes, severe skin adverse reactions, Stevens-Johnson syndrome, Lyell syndrome (toxic epidermal necrolysis), DRESS syndrome, acute generalized exanthematous pustulosis, difficulty breathing or breathlessness, asthma attack, cough + accompanied by fever.

Mild side effects

• Nausea
• vomiting
• abdominal pain
• indigestion
• diarrhea
• discomfort in the upper abdomen
• thirst
• stomatitis
• abdominal bloating
• constipation

Drug interactions

This medication should not be used with other non-steroidal anti-inflammatory drugs, aspirin, or high doses of methotrexate. Consult your doctor or pharmacist when using with glucocorticoids, digoxin, phenytoin, probenecid, sulfinpyrazone, sulfonylureas, diuretics, antihypertensive agents, ACE inhibitors, furosemide, lithium, low doses of methotrexate, and coumarin anticoagulants (e.g., warfarin).

Food interactions

Caution is required when using this medication with alcohol.

This medication is sensitive to light and should be stored in a light-protective container. Additionally, it is recommended to store the medication at room temperature between 15 and 25 degrees Celsius. Proper storage will help maintain the medication's efficacy for a long time.

Appearance

An opaque white liquid in a distinctive scented white or off-white suspension syrup.

Package unit

500 milliliters/bottle