Neximezol Tablets 40 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medicine should be swallowed with a liquid such as water. Do not chew or crush it. 1. Adults 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. If esophagitis has not healed or symptoms persist, take it for an additional 4 weeks. - Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical evaluation is needed. · Once symptoms have resolved, subsequent recurring symptoms are controlled by administering 20 mg once daily. · In adults, 20 mg may be administered once daily as needed. As-needed administration to control recurring symptoms is not recommended for patients at high risk of developing gastric or duodenal ulcers due to nonsteroidal anti-inflammatory drug use. 2) Combination therapy with antibiotics to eradicate Helicobacter pylori Administer this medicine 20 mg together with amoxicillin 1 g and clarithromycin 500 mg, twice daily for 7 days. 3) Short-term treatment of upper gastrointestinal symptoms (pain, discomfort, and burning sensation) associated with the use of nonsteroidal anti-inflammatory drugs (nonselective or selective COX-2 inhibitors) - 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical evaluation is needed. Clinical trials exceeding 4 weeks have not been conducted. 4) Patients requiring continuous nonsteroidal anti-inflammatory drug therapy - Treatment of gastric ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. The treatment period is 4∼8 weeks. - Prevention of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory drug use: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice daily. The subsequent dose should be adjusted for each patient, and treatment should continue while clinical symptoms are present. Clinical data indicate that most patients can be controlled with doses of 80 ∼ 160 mg daily. Doses greater than 80 mg daily should be divided into 2 doses. 6) Maintenance therapy following induction of prevention of recurrent bleeding due to gastric or duodenal ulcers with intravenous administration Administer 40 mg once daily for 4 weeks following induction of prevention of recurrent bleeding due to gastric or duodenal ulcers with intravenous administration. 4. Renal impairment: No dose adjustment is necessary. Use with caution in patients with severe renal failure because there is limited experience with administration in these patients. 5. Hepatic impairment: No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the dose of this medicine must not exceed 20 mg. 6. Older adults: No dose adjustment is necessary.

Children's dosage

2. Adolescents aged 12 years and older 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. If esophagitis has not healed or symptoms persist, take it for an additional 4 weeks. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical evaluation is needed. · Once symptoms have resolved, subsequent recurring symptoms are controlled by administering 20 mg once daily. 3. Children under 12 years: There is no experience with administration of this medicine to children under 12 years.

This medication should not be used in certain patients. For example, individuals who are allergic to this medication or any of its components, those with allergies to certain antibiotics, and patients taking specific heart-related medications should not use this drug. Additionally, breastfeeding women should not take this medication. Taking this drug may cause various side effects. Commonly reported gastrointestinal issues include headache, dizziness, abdominal pain, diarrhea, nausea, vomiting, while rare but serious issues like blood abnormalities or severe allergic reactions may occur. Long-term use may lead to electrolyte imbalances such as hypomagnesemia, necessitating regular blood tests. This medication may promote bacterial growth in the stomach by reducing gastric acid, so medical consultation is advised if diarrhea or infection symptoms persist. Furthermore, patients with osteoporosis or a high risk of fractures should exercise caution as long-term use may increase fracture risk. This medication may interact with other drugs, so patients taking anticoagulants, antibiotics, antivirals, or anticonvulsants should consult a doctor or pharmacist. The safety of this medication during pregnancy has not been fully established, so it should be used cautiously and under a doctor's guidance. In case of overdose, there is no specific antidote, and symptomatic treatment should be received under medical guidance. This medication should be stored out of reach of children and not transferred to other containers.

Leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, fever, angioedema, anaphylactic reaction, shock, peripheral edema, hyponatremia, hypomagnesemia, insomnia, anxiety, mental confusion, depression, aggression, hallucination, headache, dizziness, paresthesia, drowsiness, taste disorder, blurred vision, bronchospasm, pancreatitis, abdominal pain, constipation, diarrhea, abdominal bloating, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, microscopic colitis, elevated liver enzymes, hepatitis, liver failure, encephalopathy, dermatitis, pruritus, rash, urticaria, hair loss, photosensitivity, erythema multiforme, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Reye's syndrome, acute generalized exanthematous pustulosis, eosinophilia and systemic symptoms associated drug reaction, fracture, arthralgia, myalgia, muscle weakness, nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal distention, allergic reaction, back pain, chest pain, substernal pain, facial edema, facial flushing, fatigue, influenza-like illness, generalized edema, leg edema, malaise, pain, stiffness, peripheral edema, flushing, hypertension, tachycardia, thyroid swelling, irritable bowel syndrome, exacerbation of constipation, dyspepsia, dysphagia, gastrointestinal dysmotility, epigastric pain, belching, esophageal disorders, frequent bowel movements, gastroenteritis, gastrointestinal bleeding, hiccups, melena, oral disorders, pharyngeal disorders, rectal disorders, gastrointestinal symptoms, elevated serum gastrin, tongue disorders, tongue edema, ulcerative stomatitis, earache, tinnitus, anemia, hypopigmented anemia, cervical lymphadenopathy, nosebleed, leukocytosis, leukopenia, thrombocytopenia, hyperbilirubinemia, abnormal liver function, elevated ALT, elevated AST, diabetes, hyperuricemia, elevated ALP, dry mouth, vitamin B12 deficiency, weight gain, weight loss, exacerbation of arthritis, arthropathy, convulsions, fibromyalgia syndrome, hernia, rheumatoid polymyalgia, anorexia, apathy, increased appetite, confusion, exacerbation of depression, muscle hypertonicity, sensory loss, erectile dysfunction, insomnia, migraine, exacerbation of migraine, sleep disorders, tremor, visual field defect, dysmenorrhea, menstrual disorders, vaginitis, exacerbation of asthma, cough, dyspnea, laryngeal edema, pharyngitis, rhinitis, sinusitis, acne, anal pruritus, erythematous rash, papular rash, otitis media, olfactory dysfunction, loss of taste, taste distortion, urinary abnormalities, albuminuria, cystitis, dysuria, fungal infection, hematuria, frequency of urination, candidiasis, genital candidiasis, polyuria, conjunctivitis, visual disturbances, duodenitis, esophagitis, esophageal stricture, esophageal ulcer, esophageal varices, gastric ulcer, gastritis, benign polyp or nodule, Barrett's esophagus, mucosal discoloration, hernia, systemic lupus erythematosus, cutaneous lupus erythematosus, gastric gland polyp, hypocalcemia, hypokalemia, rhabdomyolysis

This medication should be stored in a tightly closed container to avoid exposure to air or moisture, and it is best kept at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's effectiveness and safety.

Appearance

Pink, round, film-coated tablet

Package unit

28 tablets/box [14 tablets x 2 PTP]