Ripifenone (Fenofibrate)

Adult dose

Fenofibrate should be taken orally at a dose of 160 mg once daily immediately after meals. Fenofibrate should be administered in conjunction with a dietary regimen. This medication should be given immediately after meals as absorption may be reduced on an empty stomach.

Child dose

There is currently no clinical data on the use of this medication in children.

This drug should not be used in patients with poor liver function. It should also be avoided in patients with severely compromised kidney function due to the risk of rhabdomyolysis. Women who are pregnant or may become pregnant, as well as breastfeeding women, should not take this medication. Patients with allergies to this drug or its components should also refrain from using it. Caution is advised for patients with gallbladder disease or a history of gallstones, as this drug may worsen gallstone formation. Patients with a history of photosensitivity reactions due to fibrate drugs or ketoprofen may experience skin hypersensitivity while taking this medication. This drug is not administered to children. Patients with liver cirrhosis or pancreatitis should also avoid this medication, particularly except for acute pancreatitis due to severe hypertriglyceridemia. Patients with lactose intolerance or certain genetic metabolic disorders should not take this drug. Patients with allergies to soybean oil, soy, or peanuts should use caution when taking this medication. Patients with mild to moderate renal impairment should have their dose decreased or the dosing interval lengthened and should be closely monitored for the potential of rhabdomyolysis. Patients with liver function abnormalities or a history of liver disease should undergo regular liver function tests, and if abnormalities are found, consider dose adjustments or discontinuation. For patients on anticoagulants or in combination with certain hyperlipidemia medications, there may be an increased risk of bleeding or muscle damage, so caution is required. Elderly individuals should have their renal and liver functions monitored regularly as adverse reactions may occur more easily due to decreased function. This drug may affect the liver or bile ducts, leading to elevated liver enzyme levels or cholestatic hepatitis, and may cause gallstones. Cutaneous reactions such as rashes, itching, and photosensitivity may occur, and rare cases of hair loss have been reported. Neurological symptoms such as dizziness, headache, and weakness may arise. Vascular issues such as thrombosis have also been reported, requiring immediate consultation with a physician if symptoms arise. If myalgia, muscle cramps, or elevated creatine kinase levels are observed, the medication should be discontinued or adjusted, particularly in patients with reduced kidney function who are at risk of rhabdomyolysis. Gastrointestinal side effects may include abdominal pain, nausea, vomiting, diarrhea, and rarely, pancreatitis may occur. While taking this medication, regular liver function tests should be conducted, and if liver enzyme levels rise significantly, treatment should be stopped. If gallstones are suspected, gallbladder examinations should be undertaken, and if stones are found, this medication should be discontinued. Hypersensitivity may result in skin rashes, hives, and in severe cases, serious skin reactions such as Stevens-Johnson syndrome, so immediate medical attention is necessary if symptoms occur. Regular blood testing is recommended as blood counts may decrease. This drug may interact with other medications, so consultation with a physician is necessary when taken with anticoagulants, hypolipidemics, antidiabetics, immunosuppressants, and others. When taken with bile acid binding resins, the absorption may be hindered, so dosing intervals should be adjusted. During pregnancy, it may harm the fetus, so women who are pregnant or may become pregnant should not take this medication, and breastfeeding women are also advised to avoid use. This medication is not to be used in children, and elderly patients should use it carefully while regularly checking renal function. In the case of overdose, since there is no specific antidote, caution is required, and it should be stored out of the reach of children.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, abnormal respiratory symptoms accompanied by cough and fever, jaundice indicating the skin or eyes turning yellow, extreme fatigue, sudden severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis,

Mild side effects

Elevated serum aminotransferase levels, liver enlargement, cholestatic hepatitis, gallstones, rash, itching, photosensitivity, hair loss, weakness, fever, dizziness, headache, peripheral neuropathy, thrombosis, elevated creatine kinase, myalgia, muscle cramps, arthralgia, gastrointestinal disturbances (abdominal pain, nausea, vomiting, diarrhea, bloating), epilepsy, decreased hemoglobin, leukopenia, eosinophilia, elevated serum creatinine and urea levels,

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. A room temperature between 1 and 30 degrees Celsius is recommended.

Appearance

White oblong film-coated tablets

Package unit

100 tablets (10 tablets x 10 PTP)