Twinon Tablets 40/5 mg

Adult dose

The recommended dose for this medication is one tablet once daily, taken with water regardless of meals. It is preferable to take it at the same time every day (e.g., in the morning). For patients with renal impairment, no dose adjustment is needed for mild to moderate cases, but severe renal impairment patients should start treatment at a lower dose and gradually increase it. Patients with liver impairment should not exceed a daily dose of 40 mg.

Child dose

Administration to pediatric patients under the age of 18 is not recommended.

This medication can pose a serious risk to the fetus during pregnancy, especially in the second and third trimesters; therefore, it should not be used by women who are pregnant or might become pregnant. This drug is contraindicated in patients with certain diseases, such as liver disease, severe hypotension, heart failure, unstable conditions after acute myocardial infarction, and biliary obstructive disease. Particular caution is needed for patients with primary aldosteronism, heart valve disease, impaired liver function, gastrointestinal disease, renal artery hypertension, patients undergoing dialysis, and the elderly when using this drug. Common symptoms while taking this medication may include dizziness and peripheral edema, but occasionally fainting or severe side effects can occur; therefore, consult medical personnel if any abnormal symptoms appear. This medication should not be taken during pregnancy, and it should be stopped immediately if pregnancy is confirmed, switching to another safe treatment method. As this medication lowers blood pressure, patients with low fluid or salt levels may experience hypotension, so it is essential to check the condition carefully before use and observe cautiously. This drug may increase potassium levels in the blood; hence, patients at risk of hyperkalemia should regularly monitor potassium levels through blood tests. Patients with impaired renal function may experience worsening kidney function while taking this drug; thus, regular blood tests to monitor kidney status are recommended. Patients with heart disease may see an increased risk of angina or myocardial infarction; therefore, they should be attentive to any changes in symptoms after taking this medication. This drug can cause drowsiness or dizziness, so caution should be exercised when driving or operating dangerous machinery while taking it. There may be interactions with other medications, so especially when taken with digoxin, lithium, warfarin, certain anti-inflammatory analgesics, or grapefruit juice, it is important to consult medical personnel. Breastfeeding women are advised not to take this drug, and special caution is necessary when treating children or the elderly. In case of overdose, serious symptoms such as hypotension, changes in heart rate, or kidney failure may appear; therefore, immediate medical treatment should be sought.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/eye mucous membranes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, consciousness confusion, visual disturbances, paralysis,

Mild side effects

Dizziness, peripheral edema, upper respiratory infections (including pharyngitis and sinusitis), urinary tract infections (including cystitis), anemia, hyperkalemia, depression, insomnia, drowsiness, headache, migraine, paresthesia, fainting, visual impairment, dizziness, tinnitus, palpitations, bradycardia, tachycardia, flushing, hypotension, orthostatic hypotension, cough, abdominal pain, dyspepsia, nausea, vomiting, dry mouth, itching, rash, hair loss, purpura, skin discoloration, sweating, eczema,

This medication is sensitive to light and should be stored in a container that does not allow light to enter. Additionally, it is preferable to store the drug at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the drug's efficacy and safety.

Appearance

For domestic use: white or whitish rectangular tablets For export: white and light gray double-layer oval tablets with both sides convex.

Package unit

30 tablets/box [(10 tablets/Alu-Alu * 3)], 30 tablets/bottle