Laxive Capsule 100 mg (Celecoxib)

Adult dosage

The minimum recommended dose of this medicine should be adjusted for each patient, and it may be administered regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, up to 400 mg per day may be administered. If no effect is observed after 6 weeks of administering 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg on the first day of administration if needed. Starting on the second day, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50 % of the recommended daily dose.

This medication may cause gastrointestinal bleeding in individuals who consume more than three alcoholic drinks daily, so it is essential to consult a physician or pharmacist before use. This medication can increase the risk of cardiovascular thrombotic events such as heart attack and stroke, so it should be used at the lowest effective dose for the shortest duration possible, and medical attention should be sought immediately if cardiovascular symptoms occur. There is a risk of serious gastrointestinal issues such as ulcers, bleeding, and perforation; hence, individuals with a history of gastrointestinal diseases or the elderly should exercise extra caution, and medical treatment should be obtained immediately if symptoms such as abdominal pain, black stools, or vomiting blood occur. Patients with a history of allergic reactions or severe impairment of liver or kidney function, those with active gastrointestinal bleeding, heart failure patients, and women who are pregnant or breastfeeding should not take this medication. Patients with compromised liver or kidney function, history of asthma, hypertension, heart failure, the elderly, and diabetics should take this medication cautiously and regularly check their health status as directed by their physician. This medication may interact with various drugs, so if you are taking other medications, you must inform your physician or pharmacist, especially if you are taking blood pressure medications, anticoagulants, antidepressants, or anticancer agents. Women who are pregnant or planning to become pregnant should consult a physician before taking this medication as it may affect reproductive capacity, and breastfeeding women should discontinue either breastfeeding or the medication. The safety and efficacy of this medication have not been established in children and adolescents, so it is better not to use it in individuals under 18 years of age. Elderly patients may have impaired kidney, liver, or heart function, requiring careful monitoring and possible dosage adjustments when using this medication. During the use of this medication, dizziness or drowsiness may occur, so it is advisable to avoid driving or operating machinery. If this medication is taken over an extended period, regular blood tests and evaluations of liver and kidney function are required; if any abnormal symptoms appear, immediate consultation with a physician should be sought. This medication may cause serious skin reactions; therefore, if symptoms like rash, blistering, fever, or itching occur, it should be discontinued immediately, and medical attention should be sought. In case of an overdose, symptoms may include vomiting, drowsiness, and gastrointestinal bleeding, and as no specific antidote exists, appropriate medical treatment should be obtained immediately.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disorders, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, headache, leg cramps, decreased sensation, migraine, neuralgia, neuropathy, paresthesia, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, exacerbation of allergies, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, listlessness, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reactions, angioedema, loss of appetite, increased appetite, depression, nervous hyperreactivity, drowsiness, fatal intracranial hemorrhage, hallucinations, worsening of epilepsy, upper respiratory infections, sinusitis, pharyngitis, rhinitis, bronchitis, bronchospasm, exacerbated bronchospasm, dyspnea, laryngitis, pneumonia, nosebleed, speech disorders, vesicular dermatitis, dermatitis, nail disorders, photosensitivity reactions, pruritus, erythematous rash, papular rash, skin disorders, dry skin, increased sweating, polycyclic erythema, exfoliative dermatitis, mucocutaneous syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash with eosinophilia and systemic symptoms, arrhythmia, left ventricular hypertrophy, angina, unstable angina, coronary artery disorders, myocardial infarction, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, vasculitis, deep vein thrombosis, intracerebral hemorrhage, solitary, wound infection, gingivitis, herpes simplex, shingles, bacterial infections, fungal infections, soft tissue infections, viral infections, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, chest tumors, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver function abnormalities, elevated ALT, elevated AST, increased γ-GTP, elevated ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, elevated blood sodium, elevated blood potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, fractures, tendon ruptures, back pain, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, nosebleed, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, tenosynovitis, contact dermatitis, injection site reactions, skin nodules, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infections, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, eye hemorrhage, retinal artery or vein occlusion, elevated blood creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, anaphylactic reactions, hallucinations, intracerebral hemorrhage, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, photosensitivity reactions, Stevens-Johnson syndrome, polycyclic erythema, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, microangiopathic glomerulonephritis, female infertility, chest pain

This medication should be stored in a tightly sealed container to prevent air exposure, at room temperature between 15 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

A blue-striped white hard capsule containing a white to light yellow powder.

Package unit

30 capsules/bottle, 100 capsules/bottle