Alzcare Tablet 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

Donepezil hydrochloride: administer 5 mg once daily at bedtime. After 15 days, reach the normal state and administer 5 mg for 4 to 6 weeks. After evaluating clinical response, the dosage may be increased up to 10 mg. Caution should be exercised for gastrointestinal adverse reactions when increasing the dosage to 10 mg. Underweight women aged 85 or older should not exceed a dosage of 5 mg daily.

Child dose

There is no experience of use in children.

This medication should not be used in certain patients. For example, people who are allergic to the ingredients included in this medication or to donepezil hydrochloride, piperidine derivatives should not take it. Pregnant women or women who may become pregnant and breastfeeding women should also avoid taking this medication. This medication contains lactose, so individuals with lactose intolerance or certain genetic conditions should refrain from use. Patients with heart diseases, particularly those with bradycardia syndrome or cardiac conduction disorders, should use this medication cautiously as it may stimulate the vagus nerve, leading to bradycardia or arrhythmias. Those with a history of peptic ulcer or those taking non-steroidal anti-inflammatory drugs should also be cautious, as it may increase gastric acid secretion and stimulate gastrointestinal motility, exacerbating ulcer symptoms. Patients with asthma or obstructive pulmonary diseases may have worsening symptoms when taking this medication, so caution is warranted. Patients with extrapyramidal disorders such as Parkinson's disease may also experience worsening symptoms due to this medication. Additionally, caution is necessary for those allergic to Tartrazine (Yellow No. 5) contained in this medication. Various adverse reactions may occur during the use of this medication. Cardiac-related issues such as syncope, bradycardia, heart block, and myocardial infarction have been reported, as well as gastrointestinal bleeding or ulcers. Liver dysfunction, cerebrovascular issues, seizures, and movement disorders may also occur. Rare but serious side effects such as rhabdomyolysis or neuroleptic malignant syndrome have also been reported. Furthermore, symptoms related to sleepiness, insomnia, hallucinations, anxiety, depression, as well as gastrointestinal symptoms like diarrhea, nausea, vomiting may commonly occur. If these symptoms are severe or persistent, consultation with a doctor is advised. This medication is specifically used for the treatment of Alzheimer's-type dementia and is not approved for other forms of dementia or memory disorders. Treatment should be conducted under the supervision of an experienced physician, and if no therapeutic effect is observed, discontinuation should be considered. Patients with cardiovascular diseases or electrolyte abnormalities are at risk for serious arrhythmias when taking this medication, so regular ECG monitoring may be necessary. Additionally, because this medication increases gastric acid secretion, patients with a history of peptic ulcers should closely monitor for worsening symptoms. This medication may affect driving or operating machinery, so caution should be exercised when starting treatment or changing dosages. Pregnant or breastfeeding women are advised against using this medication, and if necessary, it is recommended to consult a specialist and discontinue breastfeeding. This medication may interact with various drugs, so anyone taking other medications must consult with their doctor or pharmacist. Particular caution is needed when used with drugs that affect the heart, antibiotics, antidepressants, antipsychotics, and certain antiarrhythmics. In cases of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, requiring immediate medical attention for appropriate treatment. Antidotes like atropine may be used in cases of overdose with this medication. Finally, this medication should be stored out of reach of children, and transferring it to another container should be avoided.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe rash with fever, blisters, skin peeling, pain in the mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attacks, cough with fever accompanied respiratory abnormalities, yellowing of the skin or eyes (jaundice), severe lethargy, sudden and severe headaches, lightning-like headaches, seizures, confusion of consciousness, vision changes, paralysis, urination abnormalities

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• drowsiness
• tremor

This medication should be stored in a tightly sealed container to prevent air ingress, at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the efficacy of the medication.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle