Coxiwon Capsule 200 mg (Celecoxib)

Adult dosage

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily or 100 mg per dose twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily or 100 mg per dose twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, consider another treatment option. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg on the first day if needed. From the second day of administration, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment: In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may increase the risk of gastrointestinal bleeding in individuals who regularly consume three or more alcoholic drinks per day, so consultation with a doctor or pharmacist is essential. This medication can affect the cardiovascular system and may increase the risk of serious thrombotic events such as myocardial infarction or stroke. Therefore, it should only be used at the minimum effective dose for the shortest duration, and any cardiovascular symptoms should be reported to a healthcare provider immediately. Serious gastrointestinal issues such as perforation, ulcers, or bleeding may occur, particularly in individuals with a history of gastrointestinal disease or the elderly. If symptoms such as epigastric pain, indigestion, black stools, or hematemesis arise, immediate medical treatment is necessary. This medication should not be administered to patients with certain allergies, severe liver or kidney disorders, or active gastrointestinal bleeding, and should not be taken by women who are pregnant or breastfeeding. Patients with impaired liver or kidney function, asthma, heart failure, hypertension, or the elderly should use this medication with caution and undergo regular examinations if necessary. Dizziness or drowsiness may occur while taking this medication, so driving or operating machinery should be avoided. There may be interactions with other medications, so inform your healthcare provider of any medications you are taking, especially anticoagulants, diuretics, antihypertensives, and antidepressants. Women planning to become pregnant should consult before taking this medication as it may affect fertility, and it should not be taken during pregnancy for the safety of both mother and fetus. The safety and efficacy of this medication in children and adolescents have not been established, so it is advisable not to use it. Regular checks on liver function, kidney function, and blood tests should be conducted during long-term use to detect any abnormalities, and if any adverse symptoms develop, consult a healthcare provider immediately. Overdose may lead to symptoms such as lethargy, nausea, vomiting, and abdominal pain, requiring immediate medical intervention. This medication should be kept out of reach of children and should not be transferred to other containers.

Gastrointestinal bleeding, cardiovascular thromboembolic events, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, indigestion, bloating, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, headache, leg cramps, sensory impairment, migraine, neuralgia, neuropathy, sensory disturbance, cerebral infarction, aseptic meningitis, ataxia, suicidality, loss of smell, loss of taste, allergy exacerbation, allergic reactions, malaise, chest pain, fluid retention, general edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reactions, angioedema, loss of appetite, increased appetite, depression, nerve hypersensitivity, sleepiness, fatal intracranial hemorrhage, hallucinations, worsening of epilepsy, upper respiratory infection, bronchospasm, exacerbating bronchospasm, dyspnea, laryngitis, pneumonia, epistaxis, voice disorders, vesicular dermatitis, dermatitis, nail diseases, photosensitivity reactions, pruritus, erythematous rash, papular rash, skin diseases, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, mucocutaneous syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash associated with eosinophilia and systemic symptoms, arrhythmia, left ventricular hypertrophy, angina, unstable angina, coronary artery disorders, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, sinus bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, vasculitis, deep vein thrombosis, cerebral hemorrhage, solitary, wound infections, gingivitis, herpes simplex, herpes zoster, bacterial infections, fungal infections, soft tissue infections, viral infections, moniliasis, genital moniliasis, otitis media, breast pain, menopausal symptoms, fibrocystic breast disease, thoracic neoplasms, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, ALT elevation, AST elevation, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, elevated blood sodium, elevated blood potassium, increased BUN, elevated CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, elevated LDH, hypoglycemia, hyponatremia, synovial cyst, arthralgia, arthrosis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, fractures, tendon rupture, back pain, muscular stiffness, decreased hematocrit, increased hemoglobin, epistaxis, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reactions, skin nodules, ageusia, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, visual disturbances, cataracts, conjunctivitis, eye pain, glaucoma, conjunctival hemorrhage, retinal artery or vein occlusion, increased blood creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, chest pain, anaphylactic reactions, hallucinations, cerebral hemorrhage, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash associated with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change disease glomerulonephritis, female infertility

This medication must be stored in a tightly sealed container to protect it from air and moisture. A cool place with a temperature between 15 and 30 degrees Celsius is appropriate for storage. Storing it this way will help maintain the medication's efficacy for a longer time.

Appearance

A white capsule with yellow stripes filled with a white to light yellow powder

Package unit

30 capsules/bottle, 100 capsules/bottle