Ezetimibe Tablet (Ezetimibe)

Adult dosage

The recommended dosage of this medication is 10 mg once daily, administered regardless of meals. When co-administering with HMG-CoA reductase inhibitors, start the combination at the recommended initial dose of HMG-CoA reductase inhibitors, and if already on a high dose of HMG-CoA reductase inhibitors, maintain that dose while using this drug. In cases of co-administration with fenofibrate:

This medication should not be used in patients with an allergic reaction to any of its components. Patients with active liver disease or those with persistently elevated liver enzyme levels in blood tests should not use this drug in combination with certain lipid-lowering agents (statin class medications). Pregnant or breastfeeding women should avoid using this drug in combination with statin class medications or fenofibrate. Patients with severely impaired liver function or gallbladder disease, or those with severe renal dysfunction should not take this medication in combination with fenofibrate. Additionally, since this drug contains lactose, it should not be used in patients with lactose intolerance or certain genetic metabolic disorders. Patients with moderate to severe liver dysfunction may experience increased exposure to this medication, leading to unexpected side effects, thus caution is advised. This medication is generally well tolerated, but side effects such as headache, abdominal pain, diarrhea, fatigue, joint pain, and muscle pain may occur. Regular liver function tests are necessary as liver enzyme levels can increase when this drug is used with statin class medications. If symptoms such as muscle pain or weakness occur, the physician should be informed immediately, and the medication should be discontinued if necessary. Renal function should also be monitored in patients with reduced kidney function, and dosage adjustments may be required according to the physician's instructions. This drug can interact with other medications; therefore, patients taking colestipol, fibrates, cyclosporine, anticoagulants, etc., should inform their physician or pharmacist. The use of this medication during pregnancy is restricted, and it should only be used when absolutely necessary, as its safety for the fetus has not been sufficiently confirmed. Breastfeeding women are advised to avoid using this medication, as it may be excreted into breast milk. This medication is not recommended for children under 6 years of age, and children over 6 years or adolescents should take it under a physician's direction. Elderly patients can generally use it safely, but caution is needed due to possible age-related sensitivity differences. In cases of overdose, there is no specific antidote, so appropriate treatment should be administered based on symptoms, and it should be kept out of reach of children.

Serious side effects

Hives, angioedema, elevated liver aminotransferase levels, hepatitis, thrombocytopenia, pancreatitis, severe skin reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), drug reaction with eosinophilia and systemic symptoms (DRESS), severe cutaneous adverse reactions including polymorphic erythema (SCARs), drug-induced liver injury, renal failure, liver dysfunction, increased serum creatinine, hypertension

Mild side effects

• Fatigue
• abdominal pain
• diarrhea
• viral infection
• pharyngitis
• sinusitis
• joint pain
• back pain
• cough
• headache

This medication should be stored in a sealed container to protect it from air and moisture, ideally at room temperature between 1 and 30 degrees Celsius. Proper storage conditions will help maintain the medication's effectiveness and prevent deterioration.

Appearance

White to nearly white oblong tablets

Package unit

30 tablets (10 tablets/PTP x 3)