Medication info
Tugenumon 5/8 milligrams

Tugenumon 5/8 milligrams

Prescription medicationTablet경구
Ingredient · strength
Rosuvastatin Calcium›5.2mg / 1 tabletCandesartan Cilexetil›8mg / 1 tablet
Manufacturer / importer
동아에스티(주)
Appearance
Pink round film-coated tablet
Packaging
30 tablets (10 tablets/PTP x 3)
Approval status
Active

MFDS item code 201702411 · Approved 2017.05.16 · Insurance code 642507400

Summary

Main use
(Hypertension, heart failure) improvement and (hypercholesterolemia, cardiovascular disease risk) inhibition
Who takes it
Adults · Children
Adult dose
Candesartan cilexetil - Essential hypertension: The initial and maintenance dose is recommended as 8–16 mg orally once daily, and if blood pressure is not controlled after 4 weeks of 16 mg treatment, it may be increased up to a maximum of 32 mg. - Heart failure: The initial dose is recommended as 4 mg orally once daily, and the dose may be doubled at intervals of more than 2 weeks up to a maximum of 32 mg. Rosuvastatin - Primary hypercholesterolemia, etc.: The initial dose is 5 mg once daily.
Child dose
The safety and efficacy in children and adolescents under 18 years have not been established, therefore use is not recommended.

Ingredients

Manufacturer
동아에스티(주)

Efficacy & effects

(Hypertension, heart failure) improvement and (hypercholesterolemia, cardiovascular disease risk) inhibition

  • Essential hypertension
  • heart failure
  • left ventricular systolic dysfunction
  • hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • mixed dyslipidemia
  • homozygous familial hypercholesterolemia
  • dysbetalipoproteinemia
  • hypertension
  • low HDL-cholesterol levels
  • smoking
  • family history of premature coronary heart disease
View approved original text

This medication is used for patients who need to take candesartan cilexetil and rosuvastatin simultaneously. Candesartan cilexetil is mainly used as additional or alternative therapy for patients with essential hypertension and heart failure with left ventricular dysfunction. Rosuvastatin is used as an adjunct to diet for patients with dyslipidemia such as hypercholesterolemia and mixed dyslipidemia, and is also helpful for patients with homozygous familial hypercholesterolemia. Additionally, it lowers blood cholesterol and LDL-cholesterol levels, delaying the progression of atherosclerosis, and is used in patients with primary dysbetalipoproteinemia. Moreover, it helps reduce the risk of stroke, myocardial infarction, and revascularization in high-risk cardiovascular disease patients with elevated high-sensitivity C-reactive protein levels. Therefore, this medication is used for the prevention and treatment of cardiovascular disease through blood pressure control and dyslipidemia improvement.

How to take

Adult dose

Candesartan cilexetil - Essential hypertension: The initial and maintenance dose is recommended as 8–16 mg orally once daily, and if blood pressure is not controlled after 4 weeks of 16 mg treatment, it may be increased up to a maximum of 32 mg. - Heart failure: The initial dose is recommended as 4 mg orally once daily, and the dose may be doubled at intervals of more than 2 weeks up to a maximum of 32 mg. Rosuvastatin - Primary hypercholesterolemia, etc.: The initial dose is 5 mg once daily.

Child dose

The safety and efficacy in children and adolescents under 18 years have not been established, therefore use is not recommended.

Precautions

This medication can cause serious harm to the fetus and newborn, especially during pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. It should not be used in patients with allergies to this medication, severe liver dysfunction, women who are pregnant or breastfeeding, and patients with certain kidney diseases. Elderly patients, patients with high serum potassium levels, and those with weakened liver or kidney function should use this medication cautiously and require regular examinations. If muscle pain, muscle weakness, or unusual muscle symptoms occur while taking this medication, consult a doctor immediately, and if necessary, a blood test should be conducted to check for muscle damage. If liver dysfunction is suspected, the use of this medication should also be discontinued and a doctor's opinion sought, with regular testing of liver enzyme levels recommended. This medication may interact with other drugs, so it is essential to inform healthcare providers of any other medications being taken, especially when used concurrently with potassium-sparing diuretics or certain antibiotics and antifungals. Women who are pregnant or planning to become pregnant should consult with healthcare providers before taking this medication and use appropriate contraceptive methods. The safety and efficacy in children and adolescents have not been established, so this medication should not be used in these populations. In cases of overdose, seek medical attention promptly for appropriate treatment, as symptoms such as hypotension or dizziness may occur. During treatment, rapid drops in blood pressure may happen, so caution is needed when driving or operating machinery. Keep this medication out of the reach of children, and do not transfer medications to other containers.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, peeling of skin, pain in oral/ocular mucosa, difficulty breathing or shortness of breath, asthma attack, respiratory issues accompanied by cough and fever, yellowing of skin or eyes (jaundice), profound lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, coma

Mild side effects

  • Headache
  • dizziness
  • nasopharyngitis
  • local infection
  • periodontitis
  • itching
  • arthralgia
  • limb pain
  • glare
  • dyspepsia
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  • hand fractures
  • increased blood sugar
  • decreased blood sodium
  • hypoglycemia
  • nephrolithiasis
  • cough
  • erectile dysfunction
  • nausea
  • abdominal pain
  • diarrhea
  • loss of appetite
  • abdominal distension
  • weakness
  • joint pain
  • muscle cramps
  • gout
  • numbness
  • paresthesia
  • chest discomfort
  • generalized pain
  • fatigue
  • tinnitus
  • taste disturbance
  • sleep disorders
  • decreased libido
  • forgetfulness
  • loss of appetite

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to protect it from air and moisture. The recommended storage temperature is between 1 to 30 degrees Celsius.

Appearance and packaging

Appearance

Pink round film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.