Diphins 40/5 mg (Telmisartan, Amlodipine Besylate)

Adult dose

The recommended dose for adults is one tablet once daily, to be taken with water regardless of meals. It is recommended to take it at the same time each day (e.g., morning). For patients with kidney impairment, mild and moderate renal impairment do not require dose adjustment, but patients with severe renal impairment should start treatment with a lower dose and gradually increase it. For patients with liver impairment, telmisartan's dosing for mild or moderate liver impairment should not exceed 40 mg per day.

Child dose

The safety and efficacy in pediatric patients under 18 years of age have not been established, thus the administration of this medication is not recommended.

This medication can cause serious harm to the fetus if used during pregnancy, particularly in the second and third trimesters. Therefore, women who are pregnant or may become pregnant should not take it. This medication should not be administered to individuals with allergies to its ingredients or certain heart diseases, liver dysfunction, severe hypotension, or unstable heart failure following acute myocardial infarction. Patients with impaired liver function, gastrointestinal diseases, kidney diseases, elderly patients, and others should use this medication with special caution, and dose adjustment or regular monitoring may be necessary. When taking this medication, side effects such as dizziness and peripheral edema may occur, and serious adverse reactions may occur rarely, so it is crucial to consult a healthcare professional immediately if symptoms arise. Symptoms of hypotension may appear if blood pressure decreases too much, so patients who are particularly deficient in fluids or salt should carefully check their condition before taking it and monitor their blood pressure closely while on the medication. This medication may increase serum potassium levels; therefore, when taken with potassium supplements or medications containing potassium, serum potassium concentrations should be regularly monitored. Patients with poor kidney function should periodically monitor kidney function and serum electrolyte levels while taking this medication, and heart failure patients should also use it cautiously. This medication may interact with other medications, so if you are currently taking any other medications, you must inform your healthcare professional, especially if you are taking specific heart medications, diuretics, antibiotics, grapefruit juice, etc. Pregnant or breastfeeding women should not take this medication, and if pregnancy is planned or confirmed, use should be stopped immediately, and a healthcare professional should be consulted. The safety and effectiveness of this medication have not been adequately established for children and adolescents under 18 years of age, so it is not recommended for this age group. In case of overdose, symptoms such as blood pressure drops, dizziness, and arrhythmia may appear, requiring immediate emergency treatment, so caution is warranted. This medication should be kept out of reach of children, and to maintain product quality, do not transfer it to another container; it should be taken directly from its sealed package just before use.

Serious side effects

Hives, severe swelling (including angioedema), chest tightness, difficulty breathing, cold sweat, pallor, sepsis, thrombocytopenia, anaphylaxis, hyperkalemia, hypoglycemia, hyponatremia, hyperglycemia, depression, anxiety, confusion, syncope, myocardial infarction, ventricular tachycardia, arrhythmia, atrial fibrillation, vasculitis, hepatitis, jaundice, increased liver enzymes (with cholestasis), pancreatitis, gastric inflammation, angioedema, toxic skin rashes, drug rash.

Mild side effects

• Dizziness
• peripheral edema
• fainting
• drowsiness
• headache
• sensory disturbance
• taste disturbance
• tremor
• visual impairment
• lightheadedness

This medication is sensitive to light so it should be stored in a tightly closed container that prevents light penetration. Additionally, the medication should be kept away from overly hot or cold places, ideally stored at a temperature between 1°C to 30°C.

Appearance

This is a white and light gray, double convex oval tablet.

Package unit

30 tablets/box [10 tablets/PTP X 3]