Twin Plus Tablet 40/5mg

Adult dose

The recommended dosage of this medication is 1 tablet once daily, to be taken with water regardless of meals. It is recommended to take it at the same time every day (e.g., in the morning). Dosing may vary with blood pressure control: 40/5 mg, 80/5 mg, 40/10 mg, 80/10 mg. In cases of renal impairment, start with a lower dose for severe cases and gradually increase. For liver impairment patients, the daily dose is:

Child dose

Safety and efficacy in pediatric patients under 18 years old have not been established; therefore, administration of this medication is not recommended.

This medication can pose serious risks to the fetus during pregnancy, especially in the second and third trimesters; thus, women who are pregnant or may become pregnant should not take it. Additionally, patients who are allergic to any of this medication's active ingredients or similar substances, those with severe hepatic impairment, patients with significantly impaired cardiac function, and patients with hypotension should not use this medication. Patients with liver or biliary dysfunction, gastrointestinal disorders, impaired renal function, elderly patients, and patients with renal failure should use this medication with caution and follow a doctor's instructions. Common side effects include dizziness, edema, and hypotension; therefore, caution is needed when driving or operating machinery. There is a risk of elevated potassium levels in the blood, so caution is advised when taking potassium supplements or potassium-rich foods, and patients with renal impairment should have regular blood tests. Interactions may occur when used with other medications, especially in patients taking diuretics, potassium supplements, lithium, digoxin, warfarin, or non-steroidal anti-inflammatory drugs, and it is essential to consult with a doctor or pharmacist. In the case of overdose, symptoms such as hypotension, dizziness, and cardiac function decline may occur, requiring immediate medical attention. This medication is not recommended for children as its safety and efficacy have not been sufficiently established, and breastfeeding women should also avoid it. Store this medication out of reach of children, away from moisture and direct sunlight, and it is best to take it immediately after opening.

Serious side effects

Sepsis, thrombocytopenia, anaphylactic reaction, angioedema (may lead to fatal results), Stevens-Johnson syndrome, photosensitivity reaction, hepatitis, jaundice, increased liver enzymes (accompanied by cholestasis), myocardial infarction, ventricular tachycardia, arrhythmia, atrial fibrillation, vasculitis, respiratory distress, interstitial lung disease, renal impairment (including acute renal failure), angioedema, toxic epidermal necrolysis, liver dysfunction, syncope, thrombocytopenia, leukopenia, thrombocytopenia, renal

Mild side effects

• Dizziness
• peripheral edema
• upper respiratory infection
• urinary tract infection
• anemia
• hyperkalemia
• hypoglycemia
• hyponatremia
• hyperglycemia
• depression

This medication is sensitive to light and should be stored in a container that blocks light. Additionally, it is important to store it at a temperature between 1 and 30 degrees Celsius to maintain the drug's effectiveness.

Appearance

White or off-white rectangular tablet

Package unit

30 tablets/box [10 tablets/Alu-Alu X 3], 30 tablets/bottle