Twin Plus Tablet 40/10mg

Adult dose

The recommended dosage of this medication is one tablet once daily, to be taken with water regardless of meals. It is advisable to take it at the same time every day (e.g., in the morning). For patients with mild to moderate renal impairment, no dosage adjustment is needed; however, for patients with severe renal impairment, treatment should start at a lower dose and increase gradually. For patients with liver impairment, the daily dosage should not exceed 40 milligrams. In the elderly,

Child dose

The safety and efficacy of this medication in pediatric patients under 18 years of age have not been established, hence its use is not recommended.

This medication can pose serious risks to the fetus during pregnancy, especially in the second and third trimesters; therefore, it should not be taken by women who are pregnant or may become pregnant. This medication should not be given to patients with certain conditions, such as severe liver impairment, hypotension, outflow obstruction of the heart, or unstable heart failure following acute myocardial infarction. Special caution is required when using this medication in patients with conditions such as primary aldosteronism or heart valve disease, liver impairment, gastrointestinal diseases, renal artery hypertension, patients on dialysis for renal failure, and the elderly. Common side effects may include dizziness and peripheral edema, and in rare cases, severe side effects such as syncope or myocardial infarction may occur; thus, if any unusual symptoms arise, immediate consultation with healthcare providers is necessary. Use of this medication during pregnancy can result in decreased renal function in the fetus, reduction of amniotic fluid, and delayed skull formation; therefore, it should be discontinued immediately once pregnancy is confirmed. Lactating women are advised not to use this medication, and they should consult a physician if necessary. Safety and efficacy in pediatric patients under 18 years of age have not been sufficiently established, so its use is not recommended. In elderly patients, sensitivity to the drug response may be heightened; thus, it is advisable to start at a lower dose and gradually increase the dosage. Overdose may result in symptoms such as hypotension, dizziness, or impaired heart function, requiring immediate medical attention. This medication can interact with others, so it is crucial to inform healthcare providers of any other medications being taken. Dizziness or drowsiness may occur when driving or operating machinery; therefore, caution is advised. Keep this medication out of the reach of children and store it in the original container to preserve product quality. It is safest to remove the medication directly from the packaged blister before taking it.

Serious side effects

• Urticaria
• severe swelling (edema)
• hypersensitivity
• anaphylactic reactions
• angioedema
• toxic skin rash
• drug rash
• angioedema (with fatal outcomes)
• urticaria
• exfoliative dermatitis

Mild side effects

• Dizziness
• peripheral edema
• syncope
• drowsiness
• headache
• sensory disturbances
• taste disturbances
• tremors
• visual disturbances
• vertigo

This medication should be stored in a tightly closed container that excludes light, at a temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain its efficacy and prevents degradation.

Appearance

White or off-white rectangular tablet

Package unit

30 tablets/box [10 tablets/Alu-Alu X 3], 30 tablets/bottle