Astatin 20 mg (Atorvastatin Calcium Trihydrate)

Adult dosage

For the treatment of hyperlipidemia, the recommended starting dose is 10 mg once daily. Patients requiring a greater reduction in LDL cholesterol levels may start at 20 mg or 40 mg once daily. Typically, doses range from 10 to 80 mg once daily. Lipid levels should be analyzed to adjust the dose within 2 to 4 weeks of the treatment initiation. In patients with homozygous familial hypercholesterolemia, the dose should be 10 mg to 80 mg once daily.

Children's dosage

The recommended starting dose for pediatric patients (10–17 years) with heterozygous familial hypercholesterolemia is 10 mg per day, with a maximum dose of 20 mg per day. Dose adjustments should be made based on individual patient need at intervals of 4 weeks or more.

This medication may cause severe adverse effects in the muscles, so if there is severe muscle pain or weakness, or if creatine kinase levels rise significantly, use should be discontinued immediately. Patients with liver dysfunction or very elevated liver enzyme levels should not use this medication and should undergo regular liver function tests. Women who are pregnant or may become pregnant, and breastfeeding women should not use this medication, and women of childbearing potential should use appropriate contraception. Children, especially those under 10 years old, should not use this medication, and children and adolescents over 10 years old should use it cautiously under medical guidance. This medication may interact with certain drugs, which can increase or decrease its blood concentration, so it is essential to inform your doctor or pharmacist if you are taking other medications. Particular care is needed when combined with potent CYP3A4 inhibitors or certain antibiotics, antifungals, and antivirals. Patients with a history of liver disease or those who consume excessive alcohol should use this medication cautiously, as the risk of myopathy may increase, necessitating careful monitoring for muscle symptoms. During treatment with this medication, if symptoms such as muscle pain, fatigue, or fever appear, you must inform healthcare professionals immediately for further examination. If severe rashes, blisters, itching, or angioedema occurs, discontinue use immediately. Elderly patients or patients with decreased kidney function are at higher risk of muscle adverse reactions, so dose adjustments and careful observation are necessary. In case of overdose, as there is no specific antidote, management should be based on symptoms and through liver function and blood tests. Store out of reach of children and keep in the original container to prevent deterioration in quality or misuse.

Serious side effects

Hives, severe swelling (angioedema, anaphylactic edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with fever, blisters, skin peeling, mucosal pain in mouth/eyes, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and severe reactions

Mild side effects

• Weakness
• fatigue
• chest pain
• peripheral edema
• tiredness
• fever
• nasopharyngitis
• hyperglycemia
• hypoglycemia
• weight gain

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. Additionally, it is best kept at room temperature between 1 to 30 degrees Celsius. Avoid keeping it in excessively hot or cold places.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle