Ezet 10 mg Tablet (Ezetimibe)

Adult dosage

The recommended dose of this medication is 10 mg once daily, administered without regard to meals. When co-administering with HMG-CoA reductase inhibitors, it should be started at the recommended initial dose of the HMG-CoA reductase inhibitor alongside this medication, and if already receiving a high dose of the HMG-CoA reductase inhibitor, the dose of the HMG-CoA reductase inhibitor should be maintained while adding this medication. In combination with fenofibrate, patients with mixed hyperlipidemia should take either 160 mg or 200 mg of fenofibrate once daily (see Usage Precautions 4. General Precautions).

This medication should not be used in patients with an allergic reaction to its components. Co-administration with certain lipid-lowering agents is prohibited in patients with active liver disease or those with persistently elevated liver enzymes of unknown origin. Women who are pregnant or nursing should not use this medication together with certain lipid-lowering agents, and women of childbearing potential should exercise caution. Patients with severely impaired liver function or gallbladder disease should avoid co-administration with certain lipid-lowering agents. Patients with lactose intolerance should refrain from taking this medication due to its lactose content. In patients with moderate to severe liver impairment, the concentration of this medication in the body may increase, which may lead to unexpected side effects; therefore, it should be used with caution. This medication is generally well tolerated, but side effects such as headaches, abdominal pain, diarrhea, fatigue, arthralgia, low back pain, cough, dizziness, constipation, bloating, nausea, muscle pain, vomiting, gastritis, dry mouth, discomfort in the epigastric region, belching, gastrointestinal disturbances, gastroesophageal reflux disease, glossitis, palpitations, congestive heart failure, myocardial ischemia, flushing, sputum, runny nose, limb pain, diabetes, hypoglycemia, anemia, splenomegaly, sweating, rash, and itching may occur. Caution is advised when combining this medication with other lipid-lowering agents, as there may be a slight increase in the risk of elevated liver enzyme levels and muscle-related adverse reactions. If symptoms of musculoskeletal disorders such as myalgia, muscle weakness, or muscle damage occur, the patient should consult a physician immediately, and drug administration should be discontinued if necessary. Patients with severe renal impairment can use this medication without special dosage adjustments; however, caution is advised as renal impairment may increase the risk of myopathy. This medication may interact with specific drugs, so inform your doctor or pharmacist if you are taking other medications. Generally, it is advisable not to use this medication during pregnancy or breastfeeding, and if it is necessary, it should be carefully decided after consulting a specialist. Use is not recommended in children under 6 years of age, and in children over 6 years, pharmacokinetics are similar to adults, but data on long-term use are limited. It can generally be safely used in the elderly, but some elderly individuals may be more sensitive to side effects, so monitoring is required. There is no specific antidote for overdose, so appropriate treatment should be provided based on symptoms. This medication should be stored out of the reach of children and should not be transferred to other containers for safety.

Serious side effects

Urticaria, severe swelling (edema), anaphylaxis, hypersensitivity reactions including rash and angioedema, hepatitis, thrombocytopenia, pancreatitis, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), severe skin reactions including erythema multiforme (SCARs), drug-induced liver injury, headache (attributed to severe neurological symptoms)

Mild side effects

• Fatigue
• abdominal pain
• diarrhea
• viral infections
• pharyngitis
• sinusitis
• arthralgia
• low back pain
• cough
• dizziness

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container at cool room temperature. It is important to maintain the storage temperature between 1 degree Celsius and 30 degrees Celsius.

Appearance

White to nearly white, elongated tablets

Package unit

30 tablets (10 tablets/PTP x 3)