Esomeprazole Magnesium 40 mg Tablet

Adult dosage

This medication should be swallowed with liquid such as water and must not be chewed or crushed. 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: administer 40 mg once daily for 4 weeks. - If esophagitis is not treated or symptoms continue, take for another 4 weeks. - Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. · Once symptoms are alleviated, any subsequent symptoms should be managed with 20 mg once daily. · In adults, 20 mg can be dosed as needed once daily. For patients at high risk of developing gastric or duodenal ulcers due to non-steroidal anti-inflammatory drug use, it is not recommended to administer continuously as needed for symptomatic control. 2) Antibiotic combination therapy for Helicobacter pylori eradication Administer this drug at 20 mg with amoxicillin 1 g and clarithromycin 500 mg twice daily for 7 days. 3) Short-term therapy for symptoms (pain, discomfort, burning) related to non-steroidal anti-inflammatory drug (non-selective COX-2, selective) administration - 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical attention is necessary. No clinical trials have been conducted exceeding 4 weeks. 4) For patients requiring continuous non-steroidal anti-inflammatory drug administration - Treatment of gastric ulcers related to non-steroidal anti-inflammatory drug administration: 20 mg once daily. Treatment duration is 4 to 8 weeks. - Prevention of gastric and duodenal ulcers related to non-steroidal anti-inflammatory drug administration: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome A recommended initial dose is 40 mg administered twice daily. Subsequent doses should be adjusted based on the individual patient, and treatment should continue for as long as clinical symptoms are present. According to clinical data, most patients can be controlled at doses of 80 to 160 mg daily. Doses exceeding 80 mg daily should be divided into two doses. 6) Maintenance therapy after intravenous administration to prevent rebleeding due to gastric or duodenal ulcers Following intravenous administration to prevent rebleeding due to gastric or duodenal ulcers, administer 40 mg once daily for 4 weeks. 2. Adolescents aged 12 and older 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: administer 40 mg once daily for 4 weeks. If esophagitis is not treated or symptoms persist, continue for another 4 weeks. - Symptomatic treatment for gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. · Once symptoms are alleviated, any subsequent symptoms should be managed with 20 mg once daily. · In adults, 20 mg can be dosed as needed once daily. For patients at high risk of developing gastric or duodenal ulcers due to non-steroidal anti-inflammatory drug use, it is not recommended to administer continuously as needed for symptomatic control. 3. Children under 12 There is no experience administering this drug to children under the age of 12. 4. Renal impairment No dosage adjustment is necessary. Due to limited cases in severe renal failure patients, caution is advised during administration. 5. Hepatic impairment No dosage adjustment is necessary for patients with mild to moderate hepatic impairment. For patients with severe hepatic impairment, this medication should not exceed 20 mg per dose. 6. Elderly patients No dosage adjustment is necessary.

Children's dosage

Adolescents aged 12 and above 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: administer 40 mg once daily for 4 weeks. - If esophagitis is not treated or symptoms persist, continue for another 4 weeks.

This medication should not be administered to certain patients. For example, individuals allergic to this medication or its components, or those who have previously experienced hypersensitivity reactions to similar drugs, should avoid taking it. Caution is also required for those with allergies to penicillin or macrolide antibiotics when used in combination. Patients currently on specific heart-related medications or with a history of myocardial infarction, as well as nursing women, are also advised against using this drug. This medication may cause various side effects, so any symptoms occurring should be immediately discussed with healthcare professionals. Gastrointestinal symptoms such as headache, abdominal pain, diarrhea, and vomiting may commonly occur, while rarer serious reactions like blood abnormalities, skin rashes, and difficulty in breathing have also been reported. Long-term use may lead to decreased levels of magnesium, calcium, and potassium, requiring regular testing. This drug inhibits gastric acid secretion and may increase the risk of bacterial growth in the stomach, so if diarrhea persists, infection should be checked. Additionally, long-term use may increase the risk of fractures, and caution is warranted for those at risk of osteoporosis. This medication may interact with several other drugs, so patients taking other medications must inform their physician or pharmacist. In particular, dosage adjustments or monitoring may be necessary when used with anticoagulants, antiviral agents, certain antibiotics, and anticonvulsants. Due to limited safety data during pregnancy, those who are pregnant or planning to become pregnant should consult with their doctor before use. If nursing, it is recommended to avoid this medication as it may be transmitted through breast milk. In the case of overdose, there is no specific antidote; symptomatic treatment is required, and the medication should be kept out of the reach of children to prevent accidents.

Serious side effects

Urticaria, angioedema, anaphylaxis, shock, severe allergic reactions, angioedema, urticaria, skin rashes, dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, DRESS syndrome, jaundice, hepatitis, liver failure, encephalopathy, rhabdomyolysis, severe skin reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, respiratory distress, bronchospasm, exacerbation of asthma, difficulty in breathing.

Mild side effects

• Fever
• angioedema
• peripheral edema
• insomnia
• anxiety
• confusion
• depression
• aggression
• hallucinations
• headache

This medication should be stored in a tightly closed container to prevent air or moisture from entering. The storage temperature should ideally be maintained between 1 and 30 degrees Celsius.

Appearance

Pink oblong film-coated tablet

Package unit

28 tablets (14 tablets/PTP × 2)