Calderon Injection (Cholecalciferol)

Adult administration

Administer 200,000 IU of cholecalciferol as an intramuscular injection. Adjust the dose based on the blood level of 25-hydroxy vitamin D. Ensure that the annual dosage does not exceed 600,000 IU of cholecalciferol.

Child administration

Administer 200,000 IU of cholecalciferol as an intramuscular injection. In the case of adolescents, the need for re-administration should be determined by reviewing the therapeutic effect and tolerance within 6 months.

This medication contains vitamin D, so total vitamin D intake should be considered when taken with vitamin D fortified foods or other vitamin D preparations. Blood calcium levels should be regularly checked, and if the serum calcium level exceeds 10.5 mg/dL or urinary calcium excretion is excessive, administration should be discontinued. Patients with high calcium intake should regularly check calcium levels in blood and urine for abnormalities. This medication should not be administered to patients with certain conditions, those with impaired kidney function, and women who are pregnant or breastfeeding. Various side effects may occur during use, including headaches, muscle pain, gastrointestinal disturbances, dehydration, hypertension, kidney issues, and skin rashes; if symptoms occur, immediate consultation with a healthcare professional is necessary. Blood vitamin D levels should be periodically monitored to prevent side effects from overdose, especially in the elderly or patients taking other medications who should regularly check kidney function. This medication may interact with other drugs, so if you are taking other medications, be sure to inform your healthcare professional. High-dose vitamin D supplementation during pregnancy may be harmful to the fetus; therefore, it should be avoided, and its safety has not been established for children under 12 years old. In case of overdose, stop taking it immediately, reduce calcium intake, ensure adequate hydration, and take measures to promote diuresis. This medication should not be mixed with other drugs and should be used quickly after opening; any remaining medication should be disposed of. Store in a container that blocks light as this medication is light-sensitive. Additionally, it should be stored at room temperature between 1°C and 30°C, away from excessively hot or cold conditions.

Serious side effects

Hypercalcemia, hypercalciuria, renal impairment, arrhythmias, allergic reactions (including hives), renal impairment, severe edema due to hypercalcemia, calcification of tissues in kidneys and blood vessels, excessive bone calcification.

Mild side effects

Headache, weakness, fatigue, muscle pain, loss of appetite, weight loss, growth retardation, nausea, vomiting, constipation, diarrhea, polyuria, dehydration, hypertension, calcium stones, tissue calcification in kidneys and blood vessels, excessive bone calcification, psychological symptoms, perceptual disturbances, joint pain, myasthenia, drowsiness, azotemia, allergic reactions, thirst, confusion, gas bloating, abdominal pain, metallic taste, dry mouth, rash, itching, hyperphosphatemia, hyperphosphaturia, injection site reactions.

This medication is sensitive to light, so it should be stored in a container that blocks light. Furthermore, it is best stored at room temperature between 1°C to 30°C, away from excessively hot or cold environments.

Appearance

A transparent light yellow liquid in a brown glass ampoule injection.

Package unit

5 ampoules/box [1mL/ampoule × 5], 10 ampoules/box [1mL/ampoule × 10]