Acogen Injection (Ascorbic Acid)

Adult administration

As ascorbic acid, administer 50 to 1,000 mg daily, either once or in divided doses via subcutaneous, intramuscular, or intravenous injection. Dosage should be adjusted based on age and symptoms.

Care should be taken when opening the injection container as glass shards may mix in. Extra caution is necessary when used in children or the elderly. This medication contains sodium bisulfite, which can cause serious allergic reactions or asthma attacks in individuals allergic to sulfites. Exercise caution when administering to asthma patients. Do not use this medication in the following cases: - In individuals allergic to this medication or its components. - Patients with hyperoxaluria, thalassemia. - Patients with gout or cystinuria. - Patients with G6PD deficiency, especially at high doses due to the risk of hemolysis. - Patients with kidney stones, especially if administering more than 1 gram per day. Taking this medication can cause nausea, vomiting, diarrhea, abdominal pain, fatigue, facial flushing, headache, and insomnia. Administering more than 1 gram per day can acidify urine, raising the risk of diarrhea or kidney stones. Additionally, doses exceeding 600 milligrams may result in diuretic effects. Hemolysis may occur in patients with G6PD deficiency, so caution is necessary. Excessive intake of ascorbic acid may cause precipitation of oxalate, urate, cystine, etc., in urine. This medication is typically taken orally, but injections should only be used in acute situations or when oral administration is not feasible, with a transition to oral intake as soon as possible. This medication may interact with certain drugs. Salicylates may interfere with its absorption, and the effects of this medication may be influenced when used with aspirin, nicotine, alcohol, iron supplements, some anticonvulsants, oral contraceptives, and tetracycline antibiotics. High doses may reduce the effectiveness of anticoagulants, so caution is necessary. There are also interactions with fluphenazine, barbiturates, and corticosteroids, so careful monitoring is required when used together. During pregnancy, the safety for the fetus is not clearly established, and this medication should be used only when the benefits outweigh the risks. High doses exceeding 1 gram per day during pregnancy should be avoided due to the risk of neonatal scurvy. This medication does pass into breast milk but is generally considered safe for the baby at normal doses. This medication may affect some urine test results, leading to false negatives in tests for glucose or blood in urine, or in fecal occult blood tests. Overdose may lead to diarrhea or kidney stones, and diuretic effects may occur at doses above 600 milligrams. If overdose symptoms appear, stop using the medication immediately and seek appropriate treatment. When administered via injection, there may be pain at the injection site, so care should be taken to avoid nerves and not to inject repeatedly in the same site. Particular caution is advised when administering to infants or children. If severe pain or blood return is noted upon needle insertion, the needle should be withdrawn immediately. When administering intravenously, avoid rapid injection as it may cause dizziness or vascular pain, so injections should be done slowly. This medication should be kept out of reach of children and stored in a dry place away from direct sunlight. Furthermore, transferring the drug from its original container to another may lead to a decrease in quality or risk of misuse, so it must be stored in its original container.

Serious side effects

Severe allergic reactions like anaphylaxis to sulfites, asthma attacks, hemolysis, increased risk of kidney stones and diarrhea.

Mild side effects

Nausea, vomiting, diarrhea, heartburn, abdominal cramps, fatigue, flushing, headache, insomnia, temporary mild pain at the injection site, fainting, dizziness, vascular pain.

This medication is sensitive to light and should be stored in a dark container. Additionally, to maintain its efficacy, it should be stored at a refrigerated temperature between 2 to 8 degrees Celsius.

Appearance

A clear colorless or slightly yellow injection solution in a brown vial.

Package unit

10 vials/box [20 milliliters × 10 vials]