Hygline Injection (Pre-filled) (Sodium Hyaluronate)

Adult administration

For adults, inject 1 vial into the knee joint or shoulder joint once a week for 3 consecutive weeks. The frequency of injection should be adjusted appropriately based on symptoms.

This medication should not be used in patients who have had an allergic reaction to any component of this product. Caution should be exercised when administering to patients with a history of allergic reactions to other drugs or those with liver dysfunction or a history of liver disorders. Additionally, care must be taken when injecting this medication directly into areas of skin disease or infection at the injection site. Severe allergic reactions, such as shock, can occur when using this medication, so patients should be closely monitored, and if any abnormal symptoms appear, its use should be immediately stopped, and appropriate treatment should be sought. Furthermore, allergic symptoms such as swelling of the face or around the eyes, rashes, and itching may appear; if these symptoms occur, the medication should be stopped and a doctor consulted. Temporary pain, swelling, redness, heat, and a strong feeling of pressure may occur at the injection site, so preparedness for these is necessary. Occasionally, symptoms such as nausea, vomiting, and fever may also occur; if abnormal symptoms persist, medical personnel should be notified. In cases of severe joint inflammation, it is advisable to treat the inflammation first before using this medication. After injection, care must be taken to stabilize the injection site and prevent leakage of the medication outside the joint. Aseptic conditions should be maintained during injection, and if symptoms do not improve, the treatment should be limited to three injections, after which it should be discontinued. If there is an excess of joint fluid, it is advisable to aspirate the fluid as needed before administering this medication. This medication is not suitable for intravenous injection or use in the eyes. It is advisable to use a needle gauge of 22-23 for injection. Caution should be exercised since this medication may precipitate when mixed with certain disinfectants, so they should not be used together. Women who are pregnant or may become pregnant should only use this medication with caution when the benefits outweigh the risks. The components of this medication can be transmitted through breast milk, so breastfeeding should be avoided while receiving this treatment. Safety has not been established in children, so it should be used cautiously only when necessary. Moreover, elderly patients may have reduced physical function, so it should be used with extra caution.

Serious side effects

Shock symptoms (severe allergic reaction)

Mild side effects

• Facial swelling
• facial rash
• rash
• itching
• pain at the injection site
• swelling
• redness
• warmth
• local pressure
• nausea

This medication should be stored in a sealed container to prevent air and moisture from entering, and it is best kept at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the medication.

Appearance

A colorless, transparent, viscous liquid contained in a glass or plastic tube (pre-filled syringe) sealed with rubber stoppers at both ends.

Package unit

3 vials (2.0 mL/1 vial × 3)