Vesista Tablets 10 mg (Solifenacin Succinate)

Adult dose

The usual recommended dose for adults (including older adults) is 5 mg once daily. If necessary, the dose may be increased to a maximum of 10 mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. Dosage adjustment is required for the following patients. 1. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment (creatinine clearance>30ml/min). Use with caution in patients with severe renal impairment (creatinine clearance≤30ml/min), and do not exceed 5mg once daily. 2. Patients with hepatic impairment No dose adjustment is necessary in patients with mild hepatic impairment. Use with caution in patients with moderate hepatic impairment (Child-Pugh class B), and do not exceed 5mg once daily. 3. Patients receiving a strong cytochrome P450 3A4 (CYP3A4) inhibitor Limit the maximum daily dose to 5mg in patients receiving ketoconazole or another strong CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole).

This medication is used to alleviate symptoms of overactive bladder. However, it should not be used in individuals with urinary retention, severe gastrointestinal problems, myasthenia gravis, or narrow-angle glaucoma with high eye pressure. Furthermore, those with allergies to this medication or its components, patients undergoing hemodialysis, and those with severe liver or kidney dysfunction should avoid this medication. Caution is needed for those at risk of urinary retention, gastrointestinal obstruction, slow gastrointestinal motility, and patients with severe renal or liver impairment, as dose adjustments are necessary in conjunction with strong CYP3A4 inhibitors. When taking this medication, side effects such as dry mouth, constipation, blurred vision, urinary retention, and dry eyes may occur, so if any unusual symptoms appear, consult with a doctor. In particular, dry mouth and constipation are common, and serious side effects such as gastrointestinal obstruction have been reported with high doses. Care should be taken when driving or operating machinery. Combining with other anticholinergic medications may increase effect or worsen side effects, so it is essential to consult with a doctor or pharmacist. Additionally, since this medication is metabolized in the liver, those with poor liver function or taking CYP3A4 inhibitors may require dose adjustments. Women who are pregnant or breastfeeding should consult healthcare professionals before using this medication, and safety in pediatric patients has not been established, so it is best avoided. In case of overdose, seek medical attention immediately for appropriate treatment, and it is crucial not to induce vomiting. This medication can rarely cause severe allergic reactions, angioedema, or anaphylaxis, so immediate treatment is necessary if unusual symptoms occur. Lastly, the effects of this medication typically appear after taking it for about 4 weeks, so consistent use is essential.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• fecal impaction
• colonic obstruction
• intestinal obstruction
• angioedema
• nausea

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature.

Appearance

Bright pink round film-coated tablets

Package unit

100 tablets (10 tablets/PTP packaging x 10), 10 tablets (10 tablets/PTP packaging x 1)