Hiruking Injection (Sodium Hyaluronate) (Pre-filled)

Adult administration

In adults, administer 1 vial once a week continuously for 3 weeks into the knee joint or shoulder joint. The frequency of administration should be adjusted appropriately according to symptoms.

This medication should not be used in patients with a history of allergy to any component of this medication. Caution should be exercised in patients with a history of allergic reactions to other medications, impaired liver function, or a history of liver disease. Liver function tests may be abnormal in patients with liver disease. Also, care should be taken when administering this medication if there are skin conditions or infections at the injection site, as it is injected directly into the joint. During the use of this medication, serious allergic reactions such as shock may occur, so patients must be closely monitored, and administration should be immediately stopped and appropriate treatment provided if any unusual symptoms appear. Additionally, allergic symptoms such as swelling around the face or eyes, rash, hives, or itching may occur, so treatment should be sought if such symptoms appear, and the medication should be stopped. At the injection site, temporary pain, swelling, redness, warmth, and sensation of pressure may occur, and symptoms like nausea, vomiting, and fever may also arise. In joints with significant inflammation, the use of this medication may worsen the inflammation, so it is advisable to reduce inflammation first before using it. After injection, care should be taken to stabilize the injection site and to avoid overexerting the affected area. If the medication leaks outside the joint, pain may occur, so it must be injected accurately intra-articularly. Maintaining a sterile condition during injection is essential, and administration should be limited to a maximum of three times; if symptoms do not improve, treatment should be discontinued. If there is excessive intra-articular fluid, it is recommended to aspirate the joint fluid before the injection. Intra-vascular administration is strictly prohibited, and it is not suitable for use in the eyes. A needle size of approximately 22-23 gauge is appropriate, and caution should be exercised as some disinfectants may cause precipitation of the medication. Pregnant women or those at risk of pregnancy should only use this medication cautiously, as its safety has not been fully established, when the benefits of treatment justify the risks. This medication can be transmitted through breast milk, so breastfeeding should be avoided during treatment. The safety for children has not been sufficiently established; thus, it should only be used cautiously when necessary. Elderly patients may have reduced physical function, so caution is needed when using this medication.

Serious side effects

Shock symptoms

Mild side effects

Hypersensitivity, edema (facial, eyelids, etc.), facial flushing, rarely rash, itching, pain (mainly transient pain after administration), swelling, rarely ascites, redness, warmth, local severe pressure sensation, nausea, vomiting, fever

This medication should be stored in a sealed container to prevent contact with air and at a temperature between 1 and 30 degrees Celsius, which is room temperature. Proper storage helps maintain the medication's effectiveness.

Appearance

A colorless, transparent, viscous liquid contained in a glass vial or plastic syringe (pre-filled) sealed with rubber stoppers at both ends.

Package unit

2.0mL (1 vial) X 1, 2.0mL (1 vial) X 3