HaruNic 5 Joo (Sodium Hyaluronate) (Pre-filled)

Adult administration

As sodium hyaluronate, administer 25mg once a week for 5 consecutive weeks into the knee joint space or shoulder joint (subacromial bursa or bicipital tendon sheath); modify the number of injections according to symptoms. Administration should be conducted under strict aseptic conditions as it is injected into the knee joint space.

This medicine should not be used in certain patients. If you have ever had an allergy to this medication or its components, do not administer it. Do not use this medication if there is an infection or skin disease around the joint. Caution is required for those with liver function problems or a history of liver disease. Those with an allergy to avian proteins should not use this medication. Serious reactions such as shock may occur after use, so the condition should be well monitored afterwards. If symptoms of allergy such as swelling around the face or eyes, rash, or itching occur, use should be immediately stopped and treatment sought. Be aware that temporary pain, swelling, redness, or warmth may occur at the injection site. Nausea, vomiting, fever, and headache may also occur. If there is severe inflammation in the joint, it is recommended to reduce the inflammation before using this medication. After administration, it is necessary to stabilize the joint area and avoid excessive movement. If the medication leaks outside the joint, pain may occur, hence it must be injected accurately into the joint. In patients with inflammatory arthritis such as rheumatoid arthritis or gout arthritis, symptoms may temporarily worsen. It is advisable to avoid vigorous exercise or weight-bearing activities for 48 hours after injection. The concomitant use with other intra-articular injectables is not recommended due to unverified safety and efficacy. For women who are pregnant or may become pregnant, the use of this medication should be carefully considered, and it should be avoided during breastfeeding. For children, safety has not been sufficiently confirmed, so it should only be used cautiously when necessary. Elderly individuals may have reduced bodily function, hence should use it more carefully. Maintain aseptic conditions during injection and only administer up to a maximum of 5 times if symptoms do not improve. If there is excess fluid in the joint, it is advisable to remove it before injection. This medication is prohibited from being administered intravenously or for ocular use. A proper size needle should be used that is suitable for the viscosity of this medication, and care should be taken to ensure the contents are evenly mixed by gently shaking the ampoule. When opening the ampoule, it should be cleaned to prevent foreign substances from entering before cutting. Be cautious as it may react with certain disinfectants causing precipitation. This medication is for single use, hence any remaining medication after opening should be discarded.

Serious side effects

• Hives
• swelling (facial, eyelids, etc.)
• shock

Mild side effects

• Facial flushing
• itching
• rash
• transient pain
• swelling
• redness
• warmth
• severe localized pressure sensation
• petechiae
• nausea

This medication should be stored in a sealed container to prevent air from entering, at a temperature between 1°C and 30°C at room temperature. This will help maintain the efficacy of the medication and prevent deterioration.

Appearance

A colorless, transparent, viscous liquid filled in a glass vial sealed with rubber stoppers on both ends (a part of the Pre-filled Syringe System)

Package unit

1 vial (2.5mL) X 10