Beshina Tablet 5 mg (Solifenacin Succinate)

Adult dose

For adults (including elderly patients), the recommended dose is 5mg once daily. If necessary, the dose may be increased to a maximum of 10mg once daily. This drug may be taken regardless of meals and should be swallowed whole with water. Dosage adjustment is required for the following patients. 1. Patients with renal impairment No dose adjustment is required for patients with mild or moderate renal impairment (creatinine clearance>30ml/min). For patients with severe renal impairment (creatinine clearance≤30ml/min), use with caution and do not exceed 5mg once daily. 2. Patients with hepatic impairment No dose adjustment is required for patients with mild hepatic impairment. For patients with moderate hepatic impairment (Child-Pugh class B), use with caution and do not exceed 5mg once daily. 3. Patients receiving potent cytochrome P450 3A4 (CYP3A4) inhibitors For patients receiving ketoconazole or another potent CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This medication should not be used in patients with certain conditions. For example, it should not be administered to patients with urinary retention symptoms, severe gastrointestinal conditions, myasthenia gravis, or narrow-angle glaucoma. Additionally, it should be avoided by individuals who have allergic reactions to this medication, patients undergoing dialysis, and those with severe liver or kidney dysfunction. There are also patients for whom careful administration is required. Patients at risk of urinary blockage or decreased gastrointestinal motility, as well as those with severe renal and liver impairment, may need dose adjustments. Care should also be taken when used in combination with certain medications, and patients with autonomic nervous system problems should be cautious. When taking this medication, be aware that side effects such as dry mouth, constipation, blurred vision, dry eyes, nausea, indigestion, abdominal pain, vomiting, urinary tract infections, influenza, pharyngitis, dizziness, depression, lower limb edema, fatigue, cough, hypertension, difficulty urinating, decreased urinary flow, post-void residual volume, cystitis, rhinitis, vomiting, gastroesophageal reflux disease, peripheral edema, headaches, hallucinations, drowsiness, delirium, renal impairment, itching, rash, erythema multiforme, exfoliative dermatitis, atrial fibrillation, palpitations, and tachycardia may occur. Severe allergic reactions, including hives, severe swelling, angioedema, chest tightness, difficulty breathing, anaphylaxis, vascular edema, severe rash, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice of the skin or eyes, severe lethargy, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis, and drastically reduced urine output are also noted. This medication can affect driving or operating machinery, so caution is advised during use. When used in conjunction with other anticholinergic medications, the effects may be enhanced or side effects may be worsened, so be sure to inform the healthcare provider. The drug is metabolized in the liver, so in patients with reduced liver function or when used with certain strong hepatic enzyme inhibitors, the dosage should be reduced. Pregnant or nursing women should consult a physician before using this medication, and particularly during breastfeeding, it is advisable to avoid use. It is not recommended for children, as safety and effectiveness have not been established. In case of overdose, immediate medical attention should be sought, and appropriate treatment should be administered according to the symptoms. Before taking this medication, inform the healthcare provider of any existing conditions or medications being taken, and seek expert assistance if any abnormal reactions or uncomfortable symptoms occur.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• fecal impaction
• colonic obstruction
• intestinal obstruction
• angioedema
• nausea

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. It is best to keep the medication at room temperature between 1 to 30 degrees Celsius, avoiding extreme temperatures.

Appearance

Bright yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle